The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

TNF is a major therapeutic target for rheumatoid arthritis (RA) and synovial fibroblasts are central to the pathogenesis of RA. Here the authors dissect TNF-induced death and activation signalling in RA synovial fibroblasts and TNF-driven arthritis and indicate that a successful therapeutic strategy...

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Autores principales:	Marietta Armaka, Caroline Ospelt, Manolis Pasparakis, George Kollias
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e6afce598f94bed818dc48303d8b5ef
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spelling	oai:doaj.org-article:6e6afce598f94bed818dc48303d8b5ef2021-12-02T15:34:04ZThe p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts10.1038/s41467-018-02935-42041-1723https://doaj.org/article/6e6afce598f94bed818dc48303d8b5ef2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02935-4https://doaj.org/toc/2041-1723TNF is a major therapeutic target for rheumatoid arthritis (RA) and synovial fibroblasts are central to the pathogenesis of RA. Here the authors dissect TNF-induced death and activation signalling in RA synovial fibroblasts and TNF-driven arthritis and indicate that a successful therapeutic strategy might be to target both IKK2 and RIPK3 at the same time.Marietta ArmakaCaroline OspeltManolis PasparakisGeorge KolliasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marietta Armaka Caroline Ospelt Manolis Pasparakis George Kollias The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
description	TNF is a major therapeutic target for rheumatoid arthritis (RA) and synovial fibroblasts are central to the pathogenesis of RA. Here the authors dissect TNF-induced death and activation signalling in RA synovial fibroblasts and TNF-driven arthritis and indicate that a successful therapeutic strategy might be to target both IKK2 and RIPK3 at the same time.
format	article
author	Marietta Armaka Caroline Ospelt Manolis Pasparakis George Kollias
author_facet	Marietta Armaka Caroline Ospelt Manolis Pasparakis George Kollias
author_sort	Marietta Armaka
title	The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
title_short	The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
title_full	The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
title_fullStr	The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
title_full_unstemmed	The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
title_sort	p55tnfr-ikk2-ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6e6afce598f94bed818dc48303d8b5ef
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The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

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