Pyroptosis: A New Insight Into Eye Disease Therapy

Pyroptosis is a lytic form of programmed cell death mediated by gasdermins (GSDMs) with pore-forming activity in response to certain exogenous and endogenous stimuli. The inflammasomes are intracellular multiprotein complexes consisting of pattern recognition receptors, an adaptor protein ASC (apopt...

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Autores principales:	Yun Zhang, Yan Jiao, Xun Li, Sheng Gao, Nenghua Zhou, Jianan Duan, Meixia Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pyroptosis eye disease inflammasome NLRP3 pyroptosis inhibitors Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6e6d2079fa054291a6aabbed25888986
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spelling	oai:doaj.org-article:6e6d2079fa054291a6aabbed258889862021-12-03T06:58:57ZPyroptosis: A New Insight Into Eye Disease Therapy1663-981210.3389/fphar.2021.797110https://doaj.org/article/6e6d2079fa054291a6aabbed258889862021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.797110/fullhttps://doaj.org/toc/1663-9812Pyroptosis is a lytic form of programmed cell death mediated by gasdermins (GSDMs) with pore-forming activity in response to certain exogenous and endogenous stimuli. The inflammasomes are intracellular multiprotein complexes consisting of pattern recognition receptors, an adaptor protein ASC (apoptosis speck-like protein), and caspase-1 and cause autocatalytic activation of caspase-1, which cleaves gasdermin D (GSDMD), inducing pyroptosis accompanied by cytokine release. In recent years, the pathogenic roles of inflammasomes and pyroptosis in multiple eye diseases, including keratitis, dry eyes, cataracts, glaucoma, uveitis, age-related macular degeneration, and diabetic retinopathy, have been continuously confirmed. Inhibiting inflammasome activation and abnormal pyroptosis in eyes generally attenuates inflammation and benefits prognosis. Therefore, insight into the pathogenesis underlying pyroptosis and inflammasome development in various types of eye diseases may provide new therapeutic strategies for ocular disorders. Inhibitors of pyroptosis, such as NLRP3, caspase-1, and GSDMD inhibitors, have been proven to be effective in many eye diseases. The purpose of this article is to illuminate the mechanism underlying inflammasome activation and pyroptosis and emphasize its crucial role in various ocular disorders. In addition, we review the application of pyroptosis modulators in eye diseases.Yun ZhangYun ZhangYan JiaoXun LiXun LiSheng GaoSheng GaoNenghua ZhouJianan DuanJianan DuanMeixia ZhangMeixia ZhangFrontiers Media S.A.articlepyroptosiseye diseaseinflammasomeNLRP3pyroptosis inhibitorsTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pyroptosis eye disease inflammasome NLRP3 pyroptosis inhibitors Therapeutics. Pharmacology RM1-950
spellingShingle	pyroptosis eye disease inflammasome NLRP3 pyroptosis inhibitors Therapeutics. Pharmacology RM1-950 Yun Zhang Yun Zhang Yan Jiao Xun Li Xun Li Sheng Gao Sheng Gao Nenghua Zhou Jianan Duan Jianan Duan Meixia Zhang Meixia Zhang Pyroptosis: A New Insight Into Eye Disease Therapy
description	Pyroptosis is a lytic form of programmed cell death mediated by gasdermins (GSDMs) with pore-forming activity in response to certain exogenous and endogenous stimuli. The inflammasomes are intracellular multiprotein complexes consisting of pattern recognition receptors, an adaptor protein ASC (apoptosis speck-like protein), and caspase-1 and cause autocatalytic activation of caspase-1, which cleaves gasdermin D (GSDMD), inducing pyroptosis accompanied by cytokine release. In recent years, the pathogenic roles of inflammasomes and pyroptosis in multiple eye diseases, including keratitis, dry eyes, cataracts, glaucoma, uveitis, age-related macular degeneration, and diabetic retinopathy, have been continuously confirmed. Inhibiting inflammasome activation and abnormal pyroptosis in eyes generally attenuates inflammation and benefits prognosis. Therefore, insight into the pathogenesis underlying pyroptosis and inflammasome development in various types of eye diseases may provide new therapeutic strategies for ocular disorders. Inhibitors of pyroptosis, such as NLRP3, caspase-1, and GSDMD inhibitors, have been proven to be effective in many eye diseases. The purpose of this article is to illuminate the mechanism underlying inflammasome activation and pyroptosis and emphasize its crucial role in various ocular disorders. In addition, we review the application of pyroptosis modulators in eye diseases.
format	article
author	Yun Zhang Yun Zhang Yan Jiao Xun Li Xun Li Sheng Gao Sheng Gao Nenghua Zhou Jianan Duan Jianan Duan Meixia Zhang Meixia Zhang
author_facet	Yun Zhang Yun Zhang Yan Jiao Xun Li Xun Li Sheng Gao Sheng Gao Nenghua Zhou Jianan Duan Jianan Duan Meixia Zhang Meixia Zhang
author_sort	Yun Zhang
title	Pyroptosis: A New Insight Into Eye Disease Therapy
title_short	Pyroptosis: A New Insight Into Eye Disease Therapy
title_full	Pyroptosis: A New Insight Into Eye Disease Therapy
title_fullStr	Pyroptosis: A New Insight Into Eye Disease Therapy
title_full_unstemmed	Pyroptosis: A New Insight Into Eye Disease Therapy
title_sort	pyroptosis: a new insight into eye disease therapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6e6d2079fa054291a6aabbed25888986
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Pyroptosis: A New Insight Into Eye Disease Therapy

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