Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections

The gut microbiota is an important regulator for maintaining the organ microenvironment through effects on the gut-vital organs axis. Respiratory tract infections are one of the most widespread and harmful diseases, especially in the last 2 years. Many lines of evidence indicate that the gut microbi...

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Autores principales:	Wenxia Zhu, Yilin Wu, Hui Liu, Caini Jiang, Lili Huo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gut microbiota respiratory tract infection pediatric immune system gut–lung axis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6e7005e0f98747049403694516b5f6a4
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spelling	oai:doaj.org-article:6e7005e0f98747049403694516b5f6a42021-11-18T08:40:12ZGut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections1664-322410.3389/fimmu.2021.741233https://doaj.org/article/6e7005e0f98747049403694516b5f6a42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.741233/fullhttps://doaj.org/toc/1664-3224The gut microbiota is an important regulator for maintaining the organ microenvironment through effects on the gut-vital organs axis. Respiratory tract infections are one of the most widespread and harmful diseases, especially in the last 2 years. Many lines of evidence indicate that the gut microbiota and its metabolites can be considered in therapeutic strategies to effectively prevent and treat respiratory diseases. However, due to the different gut microbiota composition in children compared to adults and the dynamic development of the immature immune system, studies on the interaction between children’s intestinal flora and respiratory infections are still lacking. Here, we describe the changes in the gut microbiota of children with respiratory tract infections and explain the relationship between the microbiota of children with their immune function and disease development. In addition, we will provide perspectives on the direct manipulation of intestinal microbes to prevent or treat pediatric respiratory infections.Wenxia ZhuYilin WuHui LiuCaini JiangLili HuoFrontiers Media S.A.articlegut microbiotarespiratory tract infectionpediatricimmune systemgut–lung axisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut microbiota respiratory tract infection pediatric immune system gut–lung axis Immunologic diseases. Allergy RC581-607
spellingShingle	gut microbiota respiratory tract infection pediatric immune system gut–lung axis Immunologic diseases. Allergy RC581-607 Wenxia Zhu Yilin Wu Hui Liu Caini Jiang Lili Huo Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections
description	The gut microbiota is an important regulator for maintaining the organ microenvironment through effects on the gut-vital organs axis. Respiratory tract infections are one of the most widespread and harmful diseases, especially in the last 2 years. Many lines of evidence indicate that the gut microbiota and its metabolites can be considered in therapeutic strategies to effectively prevent and treat respiratory diseases. However, due to the different gut microbiota composition in children compared to adults and the dynamic development of the immature immune system, studies on the interaction between children’s intestinal flora and respiratory infections are still lacking. Here, we describe the changes in the gut microbiota of children with respiratory tract infections and explain the relationship between the microbiota of children with their immune function and disease development. In addition, we will provide perspectives on the direct manipulation of intestinal microbes to prevent or treat pediatric respiratory infections.
format	article
author	Wenxia Zhu Yilin Wu Hui Liu Caini Jiang Lili Huo
author_facet	Wenxia Zhu Yilin Wu Hui Liu Caini Jiang Lili Huo
author_sort	Wenxia Zhu
title	Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections
title_short	Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections
title_full	Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections
title_fullStr	Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections
title_full_unstemmed	Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections
title_sort	gut–lung axis: microbial crosstalk in pediatric respiratory tract infections
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6e7005e0f98747049403694516b5f6a4
work_keys_str_mv	AT wenxiazhu gutlungaxismicrobialcrosstalkinpediatricrespiratorytractinfections AT yilinwu gutlungaxismicrobialcrosstalkinpediatricrespiratorytractinfections AT huiliu gutlungaxismicrobialcrosstalkinpediatricrespiratorytractinfections AT cainijiang gutlungaxismicrobialcrosstalkinpediatricrespiratorytractinfections AT lilihuo gutlungaxismicrobialcrosstalkinpediatricrespiratorytractinfections
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Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections

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