Investigation of Origanum compactum essential oil for analgesic and anti-inflammatory activities
Origanum compactum Benth. has been widely used in moroccan traditional medicine for various therapeutic treatments. Belonging to the same genus, O. onites was found to have marked analgesic and anti-inflammatory activities. The aim of this work is to evaluate theses pharmacological properties of the...
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EDP Sciences
2021
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oai:doaj.org-article:6e737d77636b41a2ab49bc5b80b827022021-11-12T11:44:13ZInvestigation of Origanum compactum essential oil for analgesic and anti-inflammatory activities2267-124210.1051/e3sconf/202131901104https://doaj.org/article/6e737d77636b41a2ab49bc5b80b827022021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_01104.pdfhttps://doaj.org/toc/2267-1242Origanum compactum Benth. has been widely used in moroccan traditional medicine for various therapeutic treatments. Belonging to the same genus, O. onites was found to have marked analgesic and anti-inflammatory activities. The aim of this work is to evaluate theses pharmacological properties of the essential oil of O. compactum in order to provide a basis for the folkloric use of the plant. Aerial parts of plant were subjected to steam distillation, according to the French Pharmacopoeia. Male OF1 mice and male Wistar rats were used for these studies. The analgesic effect was done using Writhing test in mice and Tail-Flick test in rats. The mechanism investigation was evaluated employing an antagonism assay using naloxone, a specific antagonist of opiate receptors. Anti- inflammatory property has been studied using carrageenin and experimental trauma induced edema in rats. The essential oil of the aerial parts of Origanum compactum was found to exert central analgesic properties. Such a dose-dependent action was obtained against chemical and thermic stimuli, respectively, from the doses of 6.25 and 12.5 mg/kg and it was inhibited by a naloxone pretreatment, a specific morphinic antagonist compound. Significant and dose-dependent anti-inflammatory effects were observed on an acute inflammatory process from the dose of 100 mg/kg.Hamamouchi JamilaEl Mahi MohammedFaouzi Moulay El AbbesEDP Sciencesarticleoriganum compactumessential oilanalgesic activityanti-inflammatory activityEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 01104 (2021) |
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origanum compactum essential oil analgesic activity anti-inflammatory activity Environmental sciences GE1-350 |
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origanum compactum essential oil analgesic activity anti-inflammatory activity Environmental sciences GE1-350 Hamamouchi Jamila El Mahi Mohammed Faouzi Moulay El Abbes Investigation of Origanum compactum essential oil for analgesic and anti-inflammatory activities |
| description |
Origanum compactum Benth. has been widely used in moroccan traditional medicine for various therapeutic treatments. Belonging to the same genus, O. onites was found to have marked analgesic and anti-inflammatory activities. The aim of this work is to evaluate theses pharmacological properties of the essential oil of O. compactum in order to provide a basis for the folkloric use of the plant. Aerial parts of plant were subjected to steam distillation, according to the French Pharmacopoeia. Male OF1 mice and male Wistar rats were used for these studies. The analgesic effect was done using Writhing test in mice and Tail-Flick test in rats. The mechanism investigation was evaluated employing an antagonism assay using naloxone, a specific antagonist of opiate receptors. Anti- inflammatory property has been studied using carrageenin and experimental trauma induced edema in rats. The essential oil of the aerial parts of Origanum compactum was found to exert central analgesic properties. Such a dose-dependent action was obtained against chemical and thermic stimuli, respectively, from the doses of 6.25 and 12.5 mg/kg and it was inhibited by a naloxone pretreatment, a specific morphinic antagonist compound. Significant and dose-dependent anti-inflammatory effects were observed on an acute inflammatory process from the dose of 100 mg/kg. |
| format |
article |
| author |
Hamamouchi Jamila El Mahi Mohammed Faouzi Moulay El Abbes |
| author_facet |
Hamamouchi Jamila El Mahi Mohammed Faouzi Moulay El Abbes |
| author_sort |
Hamamouchi Jamila |
| title |
Investigation of Origanum compactum essential oil for analgesic and anti-inflammatory activities |
| title_short |
Investigation of Origanum compactum essential oil for analgesic and anti-inflammatory activities |
| title_full |
Investigation of Origanum compactum essential oil for analgesic and anti-inflammatory activities |
| title_fullStr |
Investigation of Origanum compactum essential oil for analgesic and anti-inflammatory activities |
| title_full_unstemmed |
Investigation of Origanum compactum essential oil for analgesic and anti-inflammatory activities |
| title_sort |
investigation of origanum compactum essential oil for analgesic and anti-inflammatory activities |
| publisher |
EDP Sciences |
| publishDate |
2021 |
| url |
https://doaj.org/article/6e737d77636b41a2ab49bc5b80b82702 |
| work_keys_str_mv |
AT hamamouchijamila investigationoforiganumcompactumessentialoilforanalgesicandantiinflammatoryactivities AT elmahimohammed investigationoforiganumcompactumessentialoilforanalgesicandantiinflammatoryactivities AT faouzimoulayelabbes investigationoforiganumcompactumessentialoilforanalgesicandantiinflammatoryactivities |
| _version_ |
1718430624954449920 |