Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious <named-content content-type="genus-species">Staphylococcus aureus</named-content> Disease

Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious <named-content content-type="genus-species">Staphylococcus aureus</named-content> Disease

ABSTRACT Staphylococcus aureus produces numerous virulence factors, each contributing different mechanisms to bacterial pathogenesis in a spectrum of diseases. Alpha toxin (AT), a cytolytic pore-forming toxin, plays a key role in skin and soft tissue infections and pneumonia, and a human anti-AT mon...

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Autores principales: C. Tkaczyk, M. M. Hamilton, A. Sadowska, Y. Shi, C.S. Chang, P. Chowdhury, R. Buonapane, X. Xiao, P. Warrener, J. Mediavilla, B. Kreiswirth, J. Suzich, C. K. Stover, B. R. Sellman
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/6e74eeed87f04363a6e71d969cd1965a
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