Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy

Lukas Flatz, Curdin ConradDepartment of Dermatology, University Hospital of Lausanne (CHUV), Lausanne, SwitzerlandAbstract: Psoriasis is one of the most common chronic, inflammatory, T-cell-mediated autoimmune diseases. Over the past decade, increased knowledge of disease pathogenesis has fundamenta...

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Autores principales:	Flatz L, Conrad C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/6e77cace236144b396d9ba069a414b7f
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spelling	oai:doaj.org-article:6e77cace236144b396d9ba069a414b7f2021-12-02T01:27:45ZRole of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy2230-326Xhttps://doaj.org/article/6e77cace236144b396d9ba069a414b7f2013-02-01T00:00:00Zhttp://www.dovepress.com/role-of-t-cell-mediated-inflammation-in-psoriasis-pathogenesis-and-tar-a12319https://doaj.org/toc/2230-326XLukas Flatz, Curdin ConradDepartment of Dermatology, University Hospital of Lausanne (CHUV), Lausanne, SwitzerlandAbstract: Psoriasis is one of the most common chronic, inflammatory, T-cell-mediated autoimmune diseases. Over the past decade, increased knowledge of disease pathogenesis has fundamentally changed psoriasis treatment, with the introduction of biologics, and this has led to a multitude of improved selective targets providing potential therapeutic options. Indeed, numerous pathogenesis-based treatments are currently in development, as psoriasis has also become increasingly relevant for proof-of-concept studies. The purpose of this review was to summarize current knowledge of psoriasis immunopathogenesis, focusing on the T-cell-mediated immune response and its initiation. The authors describe recent advances in psoriasis treatment and discuss pathogenesis-based therapies that are currently in development or which could be envisioned for the future. Although current biologics are well tolerated, several issues such as long-term efficacy, long-term safety, and high costs keep driving the search for new and better therapies. With further advances in understanding disease pathogenesis, more genomic data from psoriasis patients becoming available, and potentially the identification of autoantigens in psoriasis, current research should lead to the development of a growing arsenal of improved targeted treatments and to further breakthrough immunotherapies.Keywords: autoimmunity, autoimmune disease, immune response, immunopathogenesisFlatz LConrad CDove Medical PressarticleDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol 2013, Iss default, Pp 1-10 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Flatz L Conrad C Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
description	Lukas Flatz, Curdin ConradDepartment of Dermatology, University Hospital of Lausanne (CHUV), Lausanne, SwitzerlandAbstract: Psoriasis is one of the most common chronic, inflammatory, T-cell-mediated autoimmune diseases. Over the past decade, increased knowledge of disease pathogenesis has fundamentally changed psoriasis treatment, with the introduction of biologics, and this has led to a multitude of improved selective targets providing potential therapeutic options. Indeed, numerous pathogenesis-based treatments are currently in development, as psoriasis has also become increasingly relevant for proof-of-concept studies. The purpose of this review was to summarize current knowledge of psoriasis immunopathogenesis, focusing on the T-cell-mediated immune response and its initiation. The authors describe recent advances in psoriasis treatment and discuss pathogenesis-based therapies that are currently in development or which could be envisioned for the future. Although current biologics are well tolerated, several issues such as long-term efficacy, long-term safety, and high costs keep driving the search for new and better therapies. With further advances in understanding disease pathogenesis, more genomic data from psoriasis patients becoming available, and potentially the identification of autoantigens in psoriasis, current research should lead to the development of a growing arsenal of improved targeted treatments and to further breakthrough immunotherapies.Keywords: autoimmunity, autoimmune disease, immune response, immunopathogenesis
format	article
author	Flatz L Conrad C
author_facet	Flatz L Conrad C
author_sort	Flatz L
title	Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
title_short	Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
title_full	Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
title_fullStr	Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
title_full_unstemmed	Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
title_sort	role of t-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/6e77cace236144b396d9ba069a414b7f
work_keys_str_mv	AT flatzl roleoftcellmediatedinflammationinpsoriasispathogenesisandtargetedtherapy AT conradc roleoftcellmediatedinflammationinpsoriasispathogenesisandtargetedtherapy
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Role of T-cell-mediated inflammation in psoriasis: pathogenesis and targeted therapy

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