Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

Smooth muscle cells (SMCs) invade atherosclerotic lesions and expand, contributing to plaque progression. Here Misra et al. show that SMC-derived plaque cells come from a single SMC and integrin β3 in SMCs and macrophages regulate the fate, expansion and migration of SMCs during plaque formation.

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Autores principales:	Ashish Misra, Zhonghui Feng, Rachana R. Chandran, Inamul Kabir, Noemi Rotllan, Binod Aryal, Abdul Q. Sheikh, Ling Ding, Lingfeng Qin, Carlos Fernández-Hernando, George Tellides, Daniel M. Greif
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e7f80388c9f44268ac8ad087346132a
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spelling	oai:doaj.org-article:6e7f80388c9f44268ac8ad087346132a2021-12-02T14:41:16ZIntegrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells10.1038/s41467-018-04447-72041-1723https://doaj.org/article/6e7f80388c9f44268ac8ad087346132a2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04447-7https://doaj.org/toc/2041-1723Smooth muscle cells (SMCs) invade atherosclerotic lesions and expand, contributing to plaque progression. Here Misra et al. show that SMC-derived plaque cells come from a single SMC and integrin β3 in SMCs and macrophages regulate the fate, expansion and migration of SMCs during plaque formation.Ashish MisraZhonghui FengRachana R. ChandranInamul KabirNoemi RotllanBinod AryalAbdul Q. SheikhLing DingLingfeng QinCarlos Fernández-HernandoGeorge TellidesDaniel M. GreifNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashish Misra Zhonghui Feng Rachana R. Chandran Inamul Kabir Noemi Rotllan Binod Aryal Abdul Q. Sheikh Ling Ding Lingfeng Qin Carlos Fernández-Hernando George Tellides Daniel M. Greif Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
description	Smooth muscle cells (SMCs) invade atherosclerotic lesions and expand, contributing to plaque progression. Here Misra et al. show that SMC-derived plaque cells come from a single SMC and integrin β3 in SMCs and macrophages regulate the fate, expansion and migration of SMCs during plaque formation.
format	article
author	Ashish Misra Zhonghui Feng Rachana R. Chandran Inamul Kabir Noemi Rotllan Binod Aryal Abdul Q. Sheikh Ling Ding Lingfeng Qin Carlos Fernández-Hernando George Tellides Daniel M. Greif
author_facet	Ashish Misra Zhonghui Feng Rachana R. Chandran Inamul Kabir Noemi Rotllan Binod Aryal Abdul Q. Sheikh Ling Ding Lingfeng Qin Carlos Fernández-Hernando George Tellides Daniel M. Greif
author_sort	Ashish Misra
title	Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
title_short	Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
title_full	Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
title_fullStr	Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
title_full_unstemmed	Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
title_sort	integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6e7f80388c9f44268ac8ad087346132a
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Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

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