A glycoside analog of mammalian oligomannose formulated with a TLR4-stimulating adjuvant elicits HIV-1 cross-reactive antibodies

Abstract The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM197-conjugate of a previously reported oligomannose mimetic. Oligomann...

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Autores principales: Jean-François Bruxelle, Tess Kirilenko, Nino Trattnig, Yiqiu Yang, Matteo Cattin, Paul Kosma, Ralph Pantophlet
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6e82ed37f9564815b8027762ff199af6
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