Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Julien Robert-Paganin, Daniel Auguin, Anne Houdusse
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/6e873de0aea84aacbc93a135a9252b29
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:6e873de0aea84aacbc93a135a9252b29
record_format dspace
spelling oai:doaj.org-article:6e873de0aea84aacbc93a135a9252b292021-12-02T14:39:23ZHypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition10.1038/s41467-018-06191-42041-1723https://doaj.org/article/6e873de0aea84aacbc93a135a9252b292018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06191-4https://doaj.org/toc/2041-1723Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the molecular mechanisms leading to cardiac dysfunction in HCM.Julien Robert-PaganinDaniel AuguinAnne HoudusseNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julien Robert-Paganin
Daniel Auguin
Anne Houdusse
Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
description Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the molecular mechanisms leading to cardiac dysfunction in HCM.
format article
author Julien Robert-Paganin
Daniel Auguin
Anne Houdusse
author_facet Julien Robert-Paganin
Daniel Auguin
Anne Houdusse
author_sort Julien Robert-Paganin
title Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_short Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_full Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_fullStr Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_full_unstemmed Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_sort hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6e873de0aea84aacbc93a135a9252b29
work_keys_str_mv AT julienrobertpaganin hypertrophiccardiomyopathydiseaseresultsfromdisparateimpairmentsofcardiacmyosinfunctionandautoinhibition
AT danielauguin hypertrophiccardiomyopathydiseaseresultsfromdisparateimpairmentsofcardiacmyosinfunctionandautoinhibition
AT annehoudusse hypertrophiccardiomyopathydiseaseresultsfromdisparateimpairmentsofcardiacmyosinfunctionandautoinhibition
_version_ 1718390660705288192

Ejemplares similares