Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the m...

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Auteurs principaux:	Julien Robert-Paganin, Daniel Auguin, Anne Houdusse
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/6e873de0aea84aacbc93a135a9252b29
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spelling	oai:doaj.org-article:6e873de0aea84aacbc93a135a9252b292021-12-02T14:39:23ZHypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition10.1038/s41467-018-06191-42041-1723https://doaj.org/article/6e873de0aea84aacbc93a135a9252b292018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06191-4https://doaj.org/toc/2041-1723Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the molecular mechanisms leading to cardiac dysfunction in HCM.Julien Robert-PaganinDaniel AuguinAnne HoudusseNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julien Robert-Paganin Daniel Auguin Anne Houdusse Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
description	Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the molecular mechanisms leading to cardiac dysfunction in HCM.
format	article
author	Julien Robert-Paganin Daniel Auguin Anne Houdusse
author_facet	Julien Robert-Paganin Daniel Auguin Anne Houdusse
author_sort	Julien Robert-Paganin
title	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_short	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_full	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_fullStr	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_full_unstemmed	Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
title_sort	hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6e873de0aea84aacbc93a135a9252b29
work_keys_str_mv	AT julienrobertpaganin hypertrophiccardiomyopathydiseaseresultsfromdisparateimpairmentsofcardiacmyosinfunctionandautoinhibition AT danielauguin hypertrophiccardiomyopathydiseaseresultsfromdisparateimpairmentsofcardiacmyosinfunctionandautoinhibition AT annehoudusse hypertrophiccardiomyopathydiseaseresultsfromdisparateimpairmentsofcardiacmyosinfunctionandautoinhibition
_version_	1718390660705288192

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

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