The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall

ABSTRACT Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocin...

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Autores principales:	Maarten G. K. Ghequire, Susan K. Buchanan, René De Mot
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	bacteriocin colicin M diversifying recombination/selection lipid II periplasm toxin-immunity module Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6e87cad5aa754a58947e1cd657dc7bed
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spelling	oai:doaj.org-article:6e87cad5aa754a58947e1cd657dc7bed2021-11-15T15:53:26ZThe ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall10.1128/mBio.02267-172150-7511https://doaj.org/article/6e87cad5aa754a58947e1cd657dc7bed2018-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02267-17https://doaj.org/toc/2150-7511ABSTRACT Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram-negative bacteria, appears to be part of a set of polymorphic toxins equipped with such a catalytic domain (ColM) targeting lipid II. Diversifying recombination has enabled parasitism of different receptors and has also given rise to hybrid bacteriocins in which ColM is associated with another toxin module. Remarkably, ColM toxins have recruited a diverse array of immunity partners, comprising cytoplasmic membrane-associated proteins with different topologies. Together, these findings suggest that different immunity mechanisms have evolved for ColM, in contrast to bacteriocins with nuclease activities.Maarten G. K. GhequireSusan K. BuchananRené De MotAmerican Society for Microbiologyarticlebacteriocincolicin Mdiversifying recombination/selectionlipid IIperiplasmtoxin-immunity moduleMicrobiologyQR1-502ENmBio, Vol 9, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacteriocin colicin M diversifying recombination/selection lipid II periplasm toxin-immunity module Microbiology QR1-502
spellingShingle	bacteriocin colicin M diversifying recombination/selection lipid II periplasm toxin-immunity module Microbiology QR1-502 Maarten G. K. Ghequire Susan K. Buchanan René De Mot The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
description	ABSTRACT Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram-negative bacteria, appears to be part of a set of polymorphic toxins equipped with such a catalytic domain (ColM) targeting lipid II. Diversifying recombination has enabled parasitism of different receptors and has also given rise to hybrid bacteriocins in which ColM is associated with another toxin module. Remarkably, ColM toxins have recruited a diverse array of immunity partners, comprising cytoplasmic membrane-associated proteins with different topologies. Together, these findings suggest that different immunity mechanisms have evolved for ColM, in contrast to bacteriocins with nuclease activities.
format	article
author	Maarten G. K. Ghequire Susan K. Buchanan René De Mot
author_facet	Maarten G. K. Ghequire Susan K. Buchanan René De Mot
author_sort	Maarten G. K. Ghequire
title	The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_short	The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_full	The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_fullStr	The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_full_unstemmed	The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_sort	colm family, polymorphic toxins breaching the bacterial cell wall
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/6e87cad5aa754a58947e1cd657dc7bed
work_keys_str_mv	AT maartengkghequire thecolmfamilypolymorphictoxinsbreachingthebacterialcellwall AT susankbuchanan thecolmfamilypolymorphictoxinsbreachingthebacterialcellwall AT renedemot thecolmfamilypolymorphictoxinsbreachingthebacterialcellwall AT maartengkghequire colmfamilypolymorphictoxinsbreachingthebacterialcellwall AT susankbuchanan colmfamilypolymorphictoxinsbreachingthebacterialcellwall AT renedemot colmfamilypolymorphictoxinsbreachingthebacterialcellwall
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The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall

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