Schizophrenia and risk of dementia: a meta-analysis study

Laisheng Cai, Jingwei Huang Department of Neurology, The First Affiliated Hospital of Nanchang University, Jiangxi, China Background: Evidence suggests that schizophrenia may be associated with an increased risk of dementia, but results from prior studies have been inconsistent. This study aimed t...

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Autores principales:	Cai LS, Huang JW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Schizophrenia，dementia，meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6e89310565144f32ada057034f47aea5
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spelling	oai:doaj.org-article:6e89310565144f32ada057034f47aea52021-12-02T02:41:09ZSchizophrenia and risk of dementia: a meta-analysis study1178-2021https://doaj.org/article/6e89310565144f32ada057034f47aea52018-08-01T00:00:00Zhttps://www.dovepress.com/schizophrenia-and-risk-of-dementia-a-meta-analysis-study-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Laisheng Cai, Jingwei Huang Department of Neurology, The First Affiliated Hospital of Nanchang University, Jiangxi, China Background: Evidence suggests that schizophrenia may be associated with an increased risk of dementia, but results from prior studies have been inconsistent. This study aimed to estimate the relationship between schizophrenia and incident dementia using a quantitative meta-analysis. Methods: Several databases were used to gather relevant information, including PubMed, Embase, and Web of Science, with the publication date of articles limited up to December 23, 2017. All studies reported a multivariate-adjusted estimate, represented as relative risk (RR) with 95% confidence intervals (CIs), for the association between schizophrenia and risk of dementia incidence. Pooled RRs were calculated using a random-effects model. Results: Six studies met our inclusion criteria for this meta-analysis, which included 206,694 cases of dementia and 5,063,316 participants. All individuals were without dementia at baseline. Overall, the quantitative meta-analysis suggested that subjects with schizophrenia were associated with a significantly greater risk of dementia incidence (RR 2.29; 95% CI 1.35–3.88) than those without. Conclusion: The results of this meta-analysis indicate that individuals with schizophrenia may have an increased risk for the development of dementia. Future studies should explore whether schizophrenia is a modifiable risk factor for dementia. Keywords: schizophrenia, dementia, meta-analysisCai LSHuang JWDove Medical PressarticleSchizophrenia，dementia，meta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2047-2055 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schizophrenia，dementia，meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Schizophrenia，dementia，meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Cai LS Huang JW Schizophrenia and risk of dementia: a meta-analysis study
description	Laisheng Cai, Jingwei Huang Department of Neurology, The First Affiliated Hospital of Nanchang University, Jiangxi, China Background: Evidence suggests that schizophrenia may be associated with an increased risk of dementia, but results from prior studies have been inconsistent. This study aimed to estimate the relationship between schizophrenia and incident dementia using a quantitative meta-analysis. Methods: Several databases were used to gather relevant information, including PubMed, Embase, and Web of Science, with the publication date of articles limited up to December 23, 2017. All studies reported a multivariate-adjusted estimate, represented as relative risk (RR) with 95% confidence intervals (CIs), for the association between schizophrenia and risk of dementia incidence. Pooled RRs were calculated using a random-effects model. Results: Six studies met our inclusion criteria for this meta-analysis, which included 206,694 cases of dementia and 5,063,316 participants. All individuals were without dementia at baseline. Overall, the quantitative meta-analysis suggested that subjects with schizophrenia were associated with a significantly greater risk of dementia incidence (RR 2.29; 95% CI 1.35–3.88) than those without. Conclusion: The results of this meta-analysis indicate that individuals with schizophrenia may have an increased risk for the development of dementia. Future studies should explore whether schizophrenia is a modifiable risk factor for dementia. Keywords: schizophrenia, dementia, meta-analysis
format	article
author	Cai LS Huang JW
author_facet	Cai LS Huang JW
author_sort	Cai LS
title	Schizophrenia and risk of dementia: a meta-analysis study
title_short	Schizophrenia and risk of dementia: a meta-analysis study
title_full	Schizophrenia and risk of dementia: a meta-analysis study
title_fullStr	Schizophrenia and risk of dementia: a meta-analysis study
title_full_unstemmed	Schizophrenia and risk of dementia: a meta-analysis study
title_sort	schizophrenia and risk of dementia: a meta-analysis study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/6e89310565144f32ada057034f47aea5
work_keys_str_mv	AT cails schizophreniaandriskofdementiaametaanalysisstudy AT huangjw schizophreniaandriskofdementiaametaanalysisstudy
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Schizophrenia and risk of dementia: a meta-analysis study

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