Whole-genome mutational burden analysis of three pluripotency induction methods

It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic...

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Autores principales:	Kunal Bhutani, Kristopher L. Nazor, Roy Williams, Ha Tran, Heng Dai, Željko Džakula, Edward H. Cho, Andy W. C. Pang, Mahendra Rao, Han Cao, Nicholas J. Schork, Jeanne F. Loring
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e8a5319f7e748139e1e8df30b2b96e0
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spelling	oai:doaj.org-article:6e8a5319f7e748139e1e8df30b2b96e02021-12-02T15:35:41ZWhole-genome mutational burden analysis of three pluripotency induction methods10.1038/ncomms105362041-1723https://doaj.org/article/6e8a5319f7e748139e1e8df30b2b96e02016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10536https://doaj.org/toc/2041-1723It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential.Kunal BhutaniKristopher L. NazorRoy WilliamsHa TranHeng DaiŽeljko DžakulaEdward H. ChoAndy W. C. PangMahendra RaoHan CaoNicholas J. SchorkJeanne F. LoringNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring Whole-genome mutational burden analysis of three pluripotency induction methods
description	It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential.
format	article
author	Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring
author_facet	Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring
author_sort	Kunal Bhutani
title	Whole-genome mutational burden analysis of three pluripotency induction methods
title_short	Whole-genome mutational burden analysis of three pluripotency induction methods
title_full	Whole-genome mutational burden analysis of three pluripotency induction methods
title_fullStr	Whole-genome mutational burden analysis of three pluripotency induction methods
title_full_unstemmed	Whole-genome mutational burden analysis of three pluripotency induction methods
title_sort	whole-genome mutational burden analysis of three pluripotency induction methods
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6e8a5319f7e748139e1e8df30b2b96e0
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Whole-genome mutational burden analysis of three pluripotency induction methods

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