Role and Function of O-GlcNAcylation in Cancer

Cancer cells are able to reprogram their glucose metabolism and retain energy via glycolysis even under aerobic conditions. They activate the hexosamine biosynthetic pathway (HBP), and the complex interplay of O-linked N-acetylglucosaminylation (O-GlcNAcylation) via deprivation of nutrients or incre...

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Autores principales:	Jii Bum Lee, Kyoung-Ho Pyo, Hye Ryun Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	O-GlcNAcylation O-GlcNAc transferase O-GlcNAcase cellular stress cancer immune surveillance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6e8bd2548de24ebea13a9ecd381bb1cf
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spelling	oai:doaj.org-article:6e8bd2548de24ebea13a9ecd381bb1cf2021-11-11T15:29:08ZRole and Function of O-GlcNAcylation in Cancer10.3390/cancers132153652072-6694https://doaj.org/article/6e8bd2548de24ebea13a9ecd381bb1cf2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5365https://doaj.org/toc/2072-6694Cancer cells are able to reprogram their glucose metabolism and retain energy via glycolysis even under aerobic conditions. They activate the hexosamine biosynthetic pathway (HBP), and the complex interplay of O-linked N-acetylglucosaminylation (O-GlcNAcylation) via deprivation of nutrients or increase in cellular stress results in the proliferation, progression, and metastasis of cancer cells. Notably, cancer is one of the emerging diseases associated with O-GlcNAcylation. In this review, we summarize studies that delineate the role of O-GlcNAcylation in cancer, including its modulation in metastasis, function with receptor tyrosine kinases, and resistance to chemotherapeutic agents, such as cisplatin. In addition, we discuss the function of O-GlcNAcylation in eliciting immune responses associated with immune surveillance in the tumor microenvironment. O-GlcNAcylation is increasingly accepted as one of the key players involved in the activation and differentiation of T cells and macrophages. Finally, we discuss the prognostic role of O-GlcNAcylation and potential therapeutic agents such as O-linked β-N-acetylglucosamine-transferase inhibitors, which may help overcome the resistance mechanism associated with the reprogramming of glucose metabolism.Jii Bum LeeKyoung-Ho PyoHye Ryun KimMDPI AGarticleO-GlcNAcylationO-GlcNAc transferaseO-GlcNAcasecellular stresscancerimmune surveillanceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5365, p 5365 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	O-GlcNAcylation O-GlcNAc transferase O-GlcNAcase cellular stress cancer immune surveillance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	O-GlcNAcylation O-GlcNAc transferase O-GlcNAcase cellular stress cancer immune surveillance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jii Bum Lee Kyoung-Ho Pyo Hye Ryun Kim Role and Function of O-GlcNAcylation in Cancer
description	Cancer cells are able to reprogram their glucose metabolism and retain energy via glycolysis even under aerobic conditions. They activate the hexosamine biosynthetic pathway (HBP), and the complex interplay of O-linked N-acetylglucosaminylation (O-GlcNAcylation) via deprivation of nutrients or increase in cellular stress results in the proliferation, progression, and metastasis of cancer cells. Notably, cancer is one of the emerging diseases associated with O-GlcNAcylation. In this review, we summarize studies that delineate the role of O-GlcNAcylation in cancer, including its modulation in metastasis, function with receptor tyrosine kinases, and resistance to chemotherapeutic agents, such as cisplatin. In addition, we discuss the function of O-GlcNAcylation in eliciting immune responses associated with immune surveillance in the tumor microenvironment. O-GlcNAcylation is increasingly accepted as one of the key players involved in the activation and differentiation of T cells and macrophages. Finally, we discuss the prognostic role of O-GlcNAcylation and potential therapeutic agents such as O-linked β-N-acetylglucosamine-transferase inhibitors, which may help overcome the resistance mechanism associated with the reprogramming of glucose metabolism.
format	article
author	Jii Bum Lee Kyoung-Ho Pyo Hye Ryun Kim
author_facet	Jii Bum Lee Kyoung-Ho Pyo Hye Ryun Kim
author_sort	Jii Bum Lee
title	Role and Function of O-GlcNAcylation in Cancer
title_short	Role and Function of O-GlcNAcylation in Cancer
title_full	Role and Function of O-GlcNAcylation in Cancer
title_fullStr	Role and Function of O-GlcNAcylation in Cancer
title_full_unstemmed	Role and Function of O-GlcNAcylation in Cancer
title_sort	role and function of o-glcnacylation in cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6e8bd2548de24ebea13a9ecd381bb1cf
work_keys_str_mv	AT jiibumlee roleandfunctionofoglcnacylationincancer AT kyounghopyo roleandfunctionofoglcnacylationincancer AT hyeryunkim roleandfunctionofoglcnacylationincancer
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Role and Function of O-GlcNAcylation in Cancer

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