On the use of envelope following responses to estimate peripheral level compression in the auditory system

Abstract Individual estimates of cochlear compression may provide complementary information to traditional audiometric hearing thresholds in disentangling different types of peripheral cochlear damage. Here we investigated the use of the slope of envelope following response (EFR) magnitude-level fun...

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Autores principales:	Gerard Encina-Llamas, Torsten Dau, Bastian Epp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e8ded9922164416a6f0bc18f34457fc
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spelling	oai:doaj.org-article:6e8ded9922164416a6f0bc18f34457fc2021-12-02T13:24:13ZOn the use of envelope following responses to estimate peripheral level compression in the auditory system10.1038/s41598-021-85850-x2045-2322https://doaj.org/article/6e8ded9922164416a6f0bc18f34457fc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85850-xhttps://doaj.org/toc/2045-2322Abstract Individual estimates of cochlear compression may provide complementary information to traditional audiometric hearing thresholds in disentangling different types of peripheral cochlear damage. Here we investigated the use of the slope of envelope following response (EFR) magnitude-level functions obtained from four simultaneously presented amplitude modulated tones with modulation frequencies of 80–100 Hz as a proxy of peripheral level compression. Compression estimates in individual normal hearing (NH) listeners were consistent with previously reported group-averaged compression estimates based on psychoacoustical and distortion-product oto-acoustic emission (DPOAE) measures in human listeners. They were also similar to basilar membrane (BM) compression values measured invasively in non-human mammals. EFR-based compression estimates in hearing-impaired listeners were less compressive than those for the NH listeners, consistent with a reduction of BM compression. Cochlear compression was also estimated using DPOAEs in the same NH listeners. DPOAE estimates were larger (less compressive) than EFRs estimates, showing no correlation. Despite the numerical concordance between EFR-based compression estimates and group-averaged estimates from other methods, simulations using an auditory nerve (AN) model revealed that compression estimates based on EFRs might be highly influenced by contributions from off-characteristic frequency (CF) neural populations. This compromises the possibility to estimate on-CF (i.e., frequency-specific or “local”) peripheral level compression with EFRs.Gerard Encina-LlamasTorsten DauBastian EppNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gerard Encina-Llamas Torsten Dau Bastian Epp On the use of envelope following responses to estimate peripheral level compression in the auditory system
description	Abstract Individual estimates of cochlear compression may provide complementary information to traditional audiometric hearing thresholds in disentangling different types of peripheral cochlear damage. Here we investigated the use of the slope of envelope following response (EFR) magnitude-level functions obtained from four simultaneously presented amplitude modulated tones with modulation frequencies of 80–100 Hz as a proxy of peripheral level compression. Compression estimates in individual normal hearing (NH) listeners were consistent with previously reported group-averaged compression estimates based on psychoacoustical and distortion-product oto-acoustic emission (DPOAE) measures in human listeners. They were also similar to basilar membrane (BM) compression values measured invasively in non-human mammals. EFR-based compression estimates in hearing-impaired listeners were less compressive than those for the NH listeners, consistent with a reduction of BM compression. Cochlear compression was also estimated using DPOAEs in the same NH listeners. DPOAE estimates were larger (less compressive) than EFRs estimates, showing no correlation. Despite the numerical concordance between EFR-based compression estimates and group-averaged estimates from other methods, simulations using an auditory nerve (AN) model revealed that compression estimates based on EFRs might be highly influenced by contributions from off-characteristic frequency (CF) neural populations. This compromises the possibility to estimate on-CF (i.e., frequency-specific or “local”) peripheral level compression with EFRs.
format	article
author	Gerard Encina-Llamas Torsten Dau Bastian Epp
author_facet	Gerard Encina-Llamas Torsten Dau Bastian Epp
author_sort	Gerard Encina-Llamas
title	On the use of envelope following responses to estimate peripheral level compression in the auditory system
title_short	On the use of envelope following responses to estimate peripheral level compression in the auditory system
title_full	On the use of envelope following responses to estimate peripheral level compression in the auditory system
title_fullStr	On the use of envelope following responses to estimate peripheral level compression in the auditory system
title_full_unstemmed	On the use of envelope following responses to estimate peripheral level compression in the auditory system
title_sort	on the use of envelope following responses to estimate peripheral level compression in the auditory system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e8ded9922164416a6f0bc18f34457fc
work_keys_str_mv	AT gerardencinallamas ontheuseofenvelopefollowingresponsestoestimateperipherallevelcompressionintheauditorysystem AT torstendau ontheuseofenvelopefollowingresponsestoestimateperipherallevelcompressionintheauditorysystem AT bastianepp ontheuseofenvelopefollowingresponsestoestimateperipherallevelcompressionintheauditorysystem
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On the use of envelope following responses to estimate peripheral level compression in the auditory system

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