Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.

Dengue viruses (DENV) serotypes 1, 2, and 3 have been causing yearly outbreaks in Brazil. In this study, we report the re-introduction of DENV2 in the coast of São Paulo State. Partial envelope viral genes were sequenced from eighteen patients with dengue fever during the 2010 epidemic. Phylogenetic...

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Autores principales:	Camila Malta Romano, Andréia Manso de Matos, Evaldo Stanislau A Araújo, Lucy Santos Villas-Boas, Wanessa Cardoso da Silva, Olímpia M N P F Oliveira, Karina I Carvalho, Ana Carolina Mamana de Souza, Celia L Rodrigues, José Eduardo Levi, Esper G Kallas, Claudio Sergio Pannuti
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e93977afcef461eb5dfb782499b958f
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spelling	oai:doaj.org-article:6e93977afcef461eb5dfb782499b958f2021-12-02T20:19:42ZCharacterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.1932-620310.1371/journal.pone.0011811https://doaj.org/article/6e93977afcef461eb5dfb782499b958f2010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20676363/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Dengue viruses (DENV) serotypes 1, 2, and 3 have been causing yearly outbreaks in Brazil. In this study, we report the re-introduction of DENV2 in the coast of São Paulo State. Partial envelope viral genes were sequenced from eighteen patients with dengue fever during the 2010 epidemic. Phylogenetic analysis showed this strain belongs to the American/Asian genotype and was closely related to the virus that circulated in Rio de Janeiro in 2007 and 2008. The phylogeny also showed no clustering by clinical presentation, suggesting that the disease severity could not be explained by distinct variants or genotypes. The time of the most recent common ancestor of American/Asian genotype and the São Paulo and Rio de Janeiro (SP/RJ) monophyletic cluster was estimated to be around 40 and 10 years, respectively. Since this virus was first identified in Brazil in 2007, we suggest that it was already circulating in the country before causing the first documented outbreak. This is the first description of the 2010 outbreak in the State of São Paulo, Brazil, and should contribute to efforts to control and monitor the spread of DENVs in endemic areas.Camila Malta RomanoAndréia Manso de MatosEvaldo Stanislau A AraújoLucy Santos Villas-BoasWanessa Cardoso da SilvaOlímpia M N P F OliveiraKarina I CarvalhoAna Carolina Mamana de SouzaCelia L RodriguesJosé Eduardo LeviEsper G KallasClaudio Sergio PannutiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 7, p e11811 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Camila Malta Romano Andréia Manso de Matos Evaldo Stanislau A Araújo Lucy Santos Villas-Boas Wanessa Cardoso da Silva Olímpia M N P F Oliveira Karina I Carvalho Ana Carolina Mamana de Souza Celia L Rodrigues José Eduardo Levi Esper G Kallas Claudio Sergio Pannuti Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.
description	Dengue viruses (DENV) serotypes 1, 2, and 3 have been causing yearly outbreaks in Brazil. In this study, we report the re-introduction of DENV2 in the coast of São Paulo State. Partial envelope viral genes were sequenced from eighteen patients with dengue fever during the 2010 epidemic. Phylogenetic analysis showed this strain belongs to the American/Asian genotype and was closely related to the virus that circulated in Rio de Janeiro in 2007 and 2008. The phylogeny also showed no clustering by clinical presentation, suggesting that the disease severity could not be explained by distinct variants or genotypes. The time of the most recent common ancestor of American/Asian genotype and the São Paulo and Rio de Janeiro (SP/RJ) monophyletic cluster was estimated to be around 40 and 10 years, respectively. Since this virus was first identified in Brazil in 2007, we suggest that it was already circulating in the country before causing the first documented outbreak. This is the first description of the 2010 outbreak in the State of São Paulo, Brazil, and should contribute to efforts to control and monitor the spread of DENVs in endemic areas.
format	article
author	Camila Malta Romano Andréia Manso de Matos Evaldo Stanislau A Araújo Lucy Santos Villas-Boas Wanessa Cardoso da Silva Olímpia M N P F Oliveira Karina I Carvalho Ana Carolina Mamana de Souza Celia L Rodrigues José Eduardo Levi Esper G Kallas Claudio Sergio Pannuti
author_facet	Camila Malta Romano Andréia Manso de Matos Evaldo Stanislau A Araújo Lucy Santos Villas-Boas Wanessa Cardoso da Silva Olímpia M N P F Oliveira Karina I Carvalho Ana Carolina Mamana de Souza Celia L Rodrigues José Eduardo Levi Esper G Kallas Claudio Sergio Pannuti
author_sort	Camila Malta Romano
title	Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.
title_short	Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.
title_full	Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.
title_fullStr	Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.
title_full_unstemmed	Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.
title_sort	characterization of dengue virus type 2: new insights on the 2010 brazilian epidemic.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/6e93977afcef461eb5dfb782499b958f
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Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.

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