SPINDOC binds PARP1 to facilitate PARylation

SPINDOC is known to interact with Spindlin1 (SPIN1), a histone code effector protein. Here, the authors show that SPINDOC is distributed between two distinct protein complexes, one comprising SPIN1 and the other one with PARP1. Their results suggest a role for SPINDOC in the regulation of PARP1- med...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fen Yang, Jianji Chen, Bin Liu, Guozhen Gao, Manu Sebastian, Collene Jeter, Jianjun Shen, Maria D. Person, Mark T. Bedford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e94e8c12fab440b88567054e1d8610b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6e94e8c12fab440b88567054e1d8610b
record_format	dspace
spelling	oai:doaj.org-article:6e94e8c12fab440b88567054e1d8610b2021-11-08T11:06:12ZSPINDOC binds PARP1 to facilitate PARylation10.1038/s41467-021-26588-y2041-1723https://doaj.org/article/6e94e8c12fab440b88567054e1d8610b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26588-yhttps://doaj.org/toc/2041-1723SPINDOC is known to interact with Spindlin1 (SPIN1), a histone code effector protein. Here, the authors show that SPINDOC is distributed between two distinct protein complexes, one comprising SPIN1 and the other one with PARP1. Their results suggest a role for SPINDOC in the regulation of PARP1- mediated PARylation and the DNA damage response.Fen YangJianji ChenBin LiuGuozhen GaoManu SebastianCollene JeterJianjun ShenMaria D. PersonMark T. BedfordNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fen Yang Jianji Chen Bin Liu Guozhen Gao Manu Sebastian Collene Jeter Jianjun Shen Maria D. Person Mark T. Bedford SPINDOC binds PARP1 to facilitate PARylation
description	SPINDOC is known to interact with Spindlin1 (SPIN1), a histone code effector protein. Here, the authors show that SPINDOC is distributed between two distinct protein complexes, one comprising SPIN1 and the other one with PARP1. Their results suggest a role for SPINDOC in the regulation of PARP1- mediated PARylation and the DNA damage response.
format	article
author	Fen Yang Jianji Chen Bin Liu Guozhen Gao Manu Sebastian Collene Jeter Jianjun Shen Maria D. Person Mark T. Bedford
author_facet	Fen Yang Jianji Chen Bin Liu Guozhen Gao Manu Sebastian Collene Jeter Jianjun Shen Maria D. Person Mark T. Bedford
author_sort	Fen Yang
title	SPINDOC binds PARP1 to facilitate PARylation
title_short	SPINDOC binds PARP1 to facilitate PARylation
title_full	SPINDOC binds PARP1 to facilitate PARylation
title_fullStr	SPINDOC binds PARP1 to facilitate PARylation
title_full_unstemmed	SPINDOC binds PARP1 to facilitate PARylation
title_sort	spindoc binds parp1 to facilitate parylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e94e8c12fab440b88567054e1d8610b
work_keys_str_mv	AT fenyang spindocbindsparp1tofacilitateparylation AT jianjichen spindocbindsparp1tofacilitateparylation AT binliu spindocbindsparp1tofacilitateparylation AT guozhengao spindocbindsparp1tofacilitateparylation AT manusebastian spindocbindsparp1tofacilitateparylation AT collenejeter spindocbindsparp1tofacilitateparylation AT jianjunshen spindocbindsparp1tofacilitateparylation AT mariadperson spindocbindsparp1tofacilitateparylation AT marktbedford spindocbindsparp1tofacilitateparylation
_version_	1718442342989430784

SPINDOC binds PARP1 to facilitate PARylation

Ejemplares similares