Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.

<h4>Background</h4>To assess the prognostic value of early echocardiographic indices of right ventricular function and vasoactive peptides for prediction of bronchopulmonary dysplasia (BPD) or death in very preterm infants.<h4>Methods</h4>Prospective study involving 294 very...

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Autores principales:	Roland P Neumann, Sven M Schulzke, Christian Pohl, Sven Wellmann, Boris Metze, Ann-Katrin Burdensky, Vinzenz Boos, Payman Barikbin, Christoph Bührer, Christoph Czernik
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e9526668063457b8d47749e34d386ae
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spelling	oai:doaj.org-article:6e9526668063457b8d47749e34d386ae2021-12-02T20:14:17ZRight ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.1932-620310.1371/journal.pone.0257571https://doaj.org/article/6e9526668063457b8d47749e34d386ae2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257571https://doaj.org/toc/1932-6203<h4>Background</h4>To assess the prognostic value of early echocardiographic indices of right ventricular function and vasoactive peptides for prediction of bronchopulmonary dysplasia (BPD) or death in very preterm infants.<h4>Methods</h4>Prospective study involving 294 very preterm infants (median [IQR] gestational age 28.4 [26.4-30.4] weeks, birth weight 1065 [800-1380] g), of whom 57 developed BPD (oxygen supplementation at 36 weeks postmenstrual age) and 10 died. Tricuspid annular plane systolic excursion (TAPSE), right ventricular index of myocardial performance (RIMP), plasma concentrations of mid-regional pro-atrial natriuretic peptide (MR-proANP) and C-terminal pro-endothelin-1 (CT-proET1) were measured on day 7 of life.<h4>Results</h4>RIMP was significantly increased (median [IQR] 0.3 [0.23-0.38] vs 0.22 [0.15-0.29]), TAPSE decreased (median [IQR] 5.0 [5.0-6.0] vs 6.0 [5.4-7.0] mm), MR-proANP increased (median [IQR] 784 [540-936] vs 353 [247-625] pmol/L), and CT-proET1 increased (median [IQR] 249 [190-345] vs 199 [158-284] pmol/L) in infants who developed BPD or died, as compared to controls. All variables showed significant but weak correlations with each other (rS -0.182 to 0.359) and predicted BPD/death with similar accuracy (areas under receiver operator characteristic curves 0.62 to 0.77). Multiple regression revealed only RIMP and birth weight as independent predictors of BPD or death.<h4>Conclusions</h4>Vasoactive peptide concentrations and echocardiographic assessment employing standardized measures, notably RIMP, on day 7 of life are useful to identify preterm infants at increased risk for BPD or death.Roland P NeumannSven M SchulzkeChristian PohlSven WellmannBoris MetzeAnn-Katrin BurdenskyVinzenz BoosPayman BarikbinChristoph BührerChristoph CzernikPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257571 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roland P Neumann Sven M Schulzke Christian Pohl Sven Wellmann Boris Metze Ann-Katrin Burdensky Vinzenz Boos Payman Barikbin Christoph Bührer Christoph Czernik Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.
description	<h4>Background</h4>To assess the prognostic value of early echocardiographic indices of right ventricular function and vasoactive peptides for prediction of bronchopulmonary dysplasia (BPD) or death in very preterm infants.<h4>Methods</h4>Prospective study involving 294 very preterm infants (median [IQR] gestational age 28.4 [26.4-30.4] weeks, birth weight 1065 [800-1380] g), of whom 57 developed BPD (oxygen supplementation at 36 weeks postmenstrual age) and 10 died. Tricuspid annular plane systolic excursion (TAPSE), right ventricular index of myocardial performance (RIMP), plasma concentrations of mid-regional pro-atrial natriuretic peptide (MR-proANP) and C-terminal pro-endothelin-1 (CT-proET1) were measured on day 7 of life.<h4>Results</h4>RIMP was significantly increased (median [IQR] 0.3 [0.23-0.38] vs 0.22 [0.15-0.29]), TAPSE decreased (median [IQR] 5.0 [5.0-6.0] vs 6.0 [5.4-7.0] mm), MR-proANP increased (median [IQR] 784 [540-936] vs 353 [247-625] pmol/L), and CT-proET1 increased (median [IQR] 249 [190-345] vs 199 [158-284] pmol/L) in infants who developed BPD or died, as compared to controls. All variables showed significant but weak correlations with each other (rS -0.182 to 0.359) and predicted BPD/death with similar accuracy (areas under receiver operator characteristic curves 0.62 to 0.77). Multiple regression revealed only RIMP and birth weight as independent predictors of BPD or death.<h4>Conclusions</h4>Vasoactive peptide concentrations and echocardiographic assessment employing standardized measures, notably RIMP, on day 7 of life are useful to identify preterm infants at increased risk for BPD or death.
format	article
author	Roland P Neumann Sven M Schulzke Christian Pohl Sven Wellmann Boris Metze Ann-Katrin Burdensky Vinzenz Boos Payman Barikbin Christoph Bührer Christoph Czernik
author_facet	Roland P Neumann Sven M Schulzke Christian Pohl Sven Wellmann Boris Metze Ann-Katrin Burdensky Vinzenz Boos Payman Barikbin Christoph Bührer Christoph Czernik
author_sort	Roland P Neumann
title	Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.
title_short	Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.
title_full	Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.
title_fullStr	Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.
title_full_unstemmed	Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.
title_sort	right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6e9526668063457b8d47749e34d386ae
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Right ventricular function and vasoactive peptides for early prediction of bronchopulmonary dysplasia.

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