Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone

Abstract Bisphenol A (BPA) is used in the production of plastics approved for contact with feed and food. Upon entering living organisms, BPA, as a potent endocrine disruptor, negatively affects various internal organs and regulatory systems, especially in young individuals. Although previous studie...

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Autores principales:	Krystyna Makowska, Piotr Lech, Mariusz Majewski, Andrzej Rychlik, Slawomir Gonkowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e9558276a8e4558a8e9f51776f961ac
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spelling	oai:doaj.org-article:6e9558276a8e4558a8e9f51776f961ac2021-12-02T17:30:46ZBisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone10.1038/s41598-021-91529-02045-2322https://doaj.org/article/6e9558276a8e4558a8e9f51776f961ac2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91529-0https://doaj.org/toc/2045-2322Abstract Bisphenol A (BPA) is used in the production of plastics approved for contact with feed and food. Upon entering living organisms, BPA, as a potent endocrine disruptor, negatively affects various internal organs and regulatory systems, especially in young individuals. Although previous studies have described the neurotoxic effects of BPA on various tissues, it should be underlined that the putative influence of this substance on the chemical architecture of the urinary bladder intrinsic innervation has not yet been studied. One of the most important neuronal substances involved in the regulation of urinary bladder functions is vasoactive intestinal polypeptide (VIP), which primarily participates in the regulation of muscular activity and blood flow. Therefore, this study aimed to determine the influence of various doses of BPA on the distribution pattern of VIP-positive neural structures located in the wall of the porcine urinary bladder trigone using the double-immunofluorescence method. The obtained results show that BPA influence leads to an increase in the number of both neurons and nerve fibres containing VIP in the porcine urinary bladder trigone. This may indicate that VIP participates in adaptive processes of the urinary bladder evoked by BPA.Krystyna MakowskaPiotr LechMariusz MajewskiAndrzej RychlikSlawomir GonkowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Krystyna Makowska Piotr Lech Mariusz Majewski Andrzej Rychlik Slawomir Gonkowski Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone
description	Abstract Bisphenol A (BPA) is used in the production of plastics approved for contact with feed and food. Upon entering living organisms, BPA, as a potent endocrine disruptor, negatively affects various internal organs and regulatory systems, especially in young individuals. Although previous studies have described the neurotoxic effects of BPA on various tissues, it should be underlined that the putative influence of this substance on the chemical architecture of the urinary bladder intrinsic innervation has not yet been studied. One of the most important neuronal substances involved in the regulation of urinary bladder functions is vasoactive intestinal polypeptide (VIP), which primarily participates in the regulation of muscular activity and blood flow. Therefore, this study aimed to determine the influence of various doses of BPA on the distribution pattern of VIP-positive neural structures located in the wall of the porcine urinary bladder trigone using the double-immunofluorescence method. The obtained results show that BPA influence leads to an increase in the number of both neurons and nerve fibres containing VIP in the porcine urinary bladder trigone. This may indicate that VIP participates in adaptive processes of the urinary bladder evoked by BPA.
format	article
author	Krystyna Makowska Piotr Lech Mariusz Majewski Andrzej Rychlik Slawomir Gonkowski
author_facet	Krystyna Makowska Piotr Lech Mariusz Majewski Andrzej Rychlik Slawomir Gonkowski
author_sort	Krystyna Makowska
title	Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone
title_short	Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone
title_full	Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone
title_fullStr	Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone
title_full_unstemmed	Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone
title_sort	bisphenol a affects vipergic nervous structures in the porcine urinary bladder trigone
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e9558276a8e4558a8e9f51776f961ac
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_version_	1718380733147381760

Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone

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