Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.

To determine the relationship between age and gray matter structure and how interactions between gender and hemisphere impact this relationship, we examined correlations between global or regional gray matter volume and age, including interactions of gender and hemisphere, using a general linear mod...

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Autores principales:	Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Ryuta Kawashima, Hiroshi Fukuda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e95f7d8ce904b05af7cc09c57689922
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spelling	oai:doaj.org-article:6e95f7d8ce904b05af7cc09c576899222021-11-18T06:49:15ZCorrelations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.1932-620310.1371/journal.pone.0022734https://doaj.org/article/6e95f7d8ce904b05af7cc09c576899222011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21818377/?tool=EBIhttps://doaj.org/toc/1932-6203To determine the relationship between age and gray matter structure and how interactions between gender and hemisphere impact this relationship, we examined correlations between global or regional gray matter volume and age, including interactions of gender and hemisphere, using a general linear model with voxel-based and region-of-interest analyses. Brain magnetic resonance images were collected from 1460 healthy individuals aged 20-69 years; the images were linearly normalized and segmented and restored to native space for analysis of global gray matter volume. Linearly normalized images were then non-linearly normalized and smoothed for analysis of regional gray matter volume. Analysis of global gray matter volume revealed a significant negative correlation between gray matter ratio (gray matter volume divided by intracranial volume) and age in both genders, and a significant interaction effect of age × gender on the gray matter ratio. In analyzing regional gray matter volume, the gray matter volume of all regions showed significant main effects of age, and most regions, with the exception of several including the inferior parietal lobule, showed a significant age × gender interaction. Additionally, the inferior temporal gyrus showed a significant age × gender × hemisphere interaction. No regional volumes showed significant age × hemisphere interactions. Our study may contribute to clarifying the mechanism(s) of normal brain aging in each brain region.Yasuyuki TakiBenjamin ThyreauShigeo KinomuraKazunori SatoRyoi GotoRyuta KawashimaHiroshi FukudaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22734 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasuyuki Taki Benjamin Thyreau Shigeo Kinomura Kazunori Sato Ryoi Goto Ryuta Kawashima Hiroshi Fukuda Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.
description	To determine the relationship between age and gray matter structure and how interactions between gender and hemisphere impact this relationship, we examined correlations between global or regional gray matter volume and age, including interactions of gender and hemisphere, using a general linear model with voxel-based and region-of-interest analyses. Brain magnetic resonance images were collected from 1460 healthy individuals aged 20-69 years; the images were linearly normalized and segmented and restored to native space for analysis of global gray matter volume. Linearly normalized images were then non-linearly normalized and smoothed for analysis of regional gray matter volume. Analysis of global gray matter volume revealed a significant negative correlation between gray matter ratio (gray matter volume divided by intracranial volume) and age in both genders, and a significant interaction effect of age × gender on the gray matter ratio. In analyzing regional gray matter volume, the gray matter volume of all regions showed significant main effects of age, and most regions, with the exception of several including the inferior parietal lobule, showed a significant age × gender interaction. Additionally, the inferior temporal gyrus showed a significant age × gender × hemisphere interaction. No regional volumes showed significant age × hemisphere interactions. Our study may contribute to clarifying the mechanism(s) of normal brain aging in each brain region.
format	article
author	Yasuyuki Taki Benjamin Thyreau Shigeo Kinomura Kazunori Sato Ryoi Goto Ryuta Kawashima Hiroshi Fukuda
author_facet	Yasuyuki Taki Benjamin Thyreau Shigeo Kinomura Kazunori Sato Ryoi Goto Ryuta Kawashima Hiroshi Fukuda
author_sort	Yasuyuki Taki
title	Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.
title_short	Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.
title_full	Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.
title_fullStr	Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.
title_full_unstemmed	Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.
title_sort	correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/6e95f7d8ce904b05af7cc09c57689922
work_keys_str_mv	AT yasuyukitaki correlationsamongbraingraymattervolumesagegenderandhemisphereinhealthyindividuals AT benjaminthyreau correlationsamongbraingraymattervolumesagegenderandhemisphereinhealthyindividuals AT shigeokinomura correlationsamongbraingraymattervolumesagegenderandhemisphereinhealthyindividuals AT kazunorisato correlationsamongbraingraymattervolumesagegenderandhemisphereinhealthyindividuals AT ryoigoto correlationsamongbraingraymattervolumesagegenderandhemisphereinhealthyindividuals AT ryutakawashima correlationsamongbraingraymattervolumesagegenderandhemisphereinhealthyindividuals AT hiroshifukuda correlationsamongbraingraymattervolumesagegenderandhemisphereinhealthyindividuals
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Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.

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