Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters

Abstract High-intensity interval training (HIIT) is of scientific interest due its role in improving physical fitness, but the effects of HIIT on bone health need be carefully explored. Further, it is necessary to know whether HIIT effects on bone health are dependent on the physical activity levels...

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Autores principales:	Emanuel E. C. Polisel, Wladimir R. Beck, Pedro P. M. Scariot, Taciane M. M. Pejon, Claudio A. Gobatto, Fúlvia B. Manchado-Gobatto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e9912516e0f4d69b92e77de3cfc1853
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spelling	oai:doaj.org-article:6e9912516e0f4d69b92e77de3cfc18532021-12-02T17:05:12ZEffects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters10.1038/s41598-021-85585-92045-2322https://doaj.org/article/6e9912516e0f4d69b92e77de3cfc18532021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85585-9https://doaj.org/toc/2045-2322Abstract High-intensity interval training (HIIT) is of scientific interest due its role in improving physical fitness, but the effects of HIIT on bone health need be carefully explored. Further, it is necessary to know whether HIIT effects on bone health are dependent on the physical activity levels. This may be experimentally tested since we have built a large cage (LC) that allows animals to move freely, promoting an increase of spontaneous physical activity (SPA) in comparison to a small cage (SC). Thus, we examined the effects of HIIT on biophysical, biomechanical and biochemical parameters of bone tissue of C57BL/6J mice living in cages of two different sizes: small (SC) or large (LC) cages with 1320 cm2 and 4800 cm2 floor space, respectively. Male mice were subdivided into two groups within each housing type: Control (C) and Trained (T). At the end of the interventions, all mice were euthanized to extract the femur bone for biophysical, biomechanical and biochemical analyses. Based a significant interaction from two-way ANOVA, trained mice kept in large cage (but not for trained mice housed in SC) exhibited a reduction of tenacity and displacement at failure in bone. This suggests that long-term HIIT program, in addition with a more active lifestyle correlates with exerts negative effects on the bone of healthy mice. A caution must also be raised about the excessive adoption of physical training, at least regarding bone tissue. On the other hand, increased calcium was found in femur of mice housed in LC. In line with this, LC-C mice were more active (i.e. SPA) than other groups. This implies that an active lifestyle without long-term high intensity physical training seems to play a role in promoting benefits to bone tissue. Our data provides new insights for treatment of osteo-health related disorders.Emanuel E. C. PoliselWladimir R. BeckPedro P. M. ScariotTaciane M. M. PejonClaudio A. GobattoFúlvia B. Manchado-GobattoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emanuel E. C. Polisel Wladimir R. Beck Pedro P. M. Scariot Taciane M. M. Pejon Claudio A. Gobatto Fúlvia B. Manchado-Gobatto Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters
description	Abstract High-intensity interval training (HIIT) is of scientific interest due its role in improving physical fitness, but the effects of HIIT on bone health need be carefully explored. Further, it is necessary to know whether HIIT effects on bone health are dependent on the physical activity levels. This may be experimentally tested since we have built a large cage (LC) that allows animals to move freely, promoting an increase of spontaneous physical activity (SPA) in comparison to a small cage (SC). Thus, we examined the effects of HIIT on biophysical, biomechanical and biochemical parameters of bone tissue of C57BL/6J mice living in cages of two different sizes: small (SC) or large (LC) cages with 1320 cm2 and 4800 cm2 floor space, respectively. Male mice were subdivided into two groups within each housing type: Control (C) and Trained (T). At the end of the interventions, all mice were euthanized to extract the femur bone for biophysical, biomechanical and biochemical analyses. Based a significant interaction from two-way ANOVA, trained mice kept in large cage (but not for trained mice housed in SC) exhibited a reduction of tenacity and displacement at failure in bone. This suggests that long-term HIIT program, in addition with a more active lifestyle correlates with exerts negative effects on the bone of healthy mice. A caution must also be raised about the excessive adoption of physical training, at least regarding bone tissue. On the other hand, increased calcium was found in femur of mice housed in LC. In line with this, LC-C mice were more active (i.e. SPA) than other groups. This implies that an active lifestyle without long-term high intensity physical training seems to play a role in promoting benefits to bone tissue. Our data provides new insights for treatment of osteo-health related disorders.
format	article
author	Emanuel E. C. Polisel Wladimir R. Beck Pedro P. M. Scariot Taciane M. M. Pejon Claudio A. Gobatto Fúlvia B. Manchado-Gobatto
author_facet	Emanuel E. C. Polisel Wladimir R. Beck Pedro P. M. Scariot Taciane M. M. Pejon Claudio A. Gobatto Fúlvia B. Manchado-Gobatto
author_sort	Emanuel E. C. Polisel
title	Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters
title_short	Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters
title_full	Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters
title_fullStr	Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters
title_full_unstemmed	Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters
title_sort	effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e9912516e0f4d69b92e77de3cfc1853
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Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters

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