The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats

Alzheimer disease (AD) seriously harms human health and its onset is insidious. Therefore, it is of great significance to find out the pathogenesis of AD disease for improving the prevention and treatment effect of the disease. The study drew attention to the influence of E2F-1/NF-κB/GSK-3β signalin...

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Autores principales:	Mayila Tuerxun, Ajar Muhda, Lixin Yin
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	alzheimer’s disease cognitive learning ability tau protein phosphorylation e2f-1/nf-κb/gsk-3β signaling pathway Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/6e998041569946c7ad133b22a05cc7f2
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spelling	oai:doaj.org-article:6e998041569946c7ad133b22a05cc7f22021-12-01T14:41:00ZThe molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats2165-59792165-598710.1080/21655979.2021.1989261https://doaj.org/article/6e998041569946c7ad133b22a05cc7f22021-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1989261https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Alzheimer disease (AD) seriously harms human health and its onset is insidious. Therefore, it is of great significance to find out the pathogenesis of AD disease for improving the prevention and treatment effect of the disease. The study drew attention to the influence of E2F-1/NF-κB/GSK-3β signaling pathway on cognitive dysfunction of Alzheimer rats. 60 specific pathogen-free (SPF) SD rats were selected as research subjects. The, the AD model was created by injecting Aβ1-42 into hippocampus CA1 region of AD rats using a microscopic syringe. Besides, Morris water maze test and Western blot were performed to detect the cognitive function, the levels of destination protein and active oxidation products in the brain of rats. Compared to the Sham group, the escape latency and the distance of the model group significantly increased (P < 0.05), and the number of times to pass the target quadrant was significantly reduced (P < 0.05); the expression levels of E2F-1 and NF-κB protein in the hippocampus and the phosphorylation levels of Tau231, Tau262, Tau396, Tau404 and T216-GSK-3β protein of the model group were significantly increased (P < 0.05); the ROS/RNS value in the hippocampus of the model group significantly increased (P < 0.05). AD model rats exhibit obvious cognitive dysfunction, which is associated with the activation of E2F-1/NF-κB/GSK-3β signaling pathway and the heightened Tau protein phosphorylation level.Mayila TuerxunAjar MuhdaLixin YinTaylor & Francis Grouparticlealzheimer’s diseasecognitive learning abilitytau protein phosphorylatione2f-1/nf-κb/gsk-3β signaling pathwayBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 2, Pp 10000-10008 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alzheimer’s disease cognitive learning ability tau protein phosphorylation e2f-1/nf-κb/gsk-3β signaling pathway Biotechnology TP248.13-248.65
spellingShingle	alzheimer’s disease cognitive learning ability tau protein phosphorylation e2f-1/nf-κb/gsk-3β signaling pathway Biotechnology TP248.13-248.65 Mayila Tuerxun Ajar Muhda Lixin Yin The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats
description	Alzheimer disease (AD) seriously harms human health and its onset is insidious. Therefore, it is of great significance to find out the pathogenesis of AD disease for improving the prevention and treatment effect of the disease. The study drew attention to the influence of E2F-1/NF-κB/GSK-3β signaling pathway on cognitive dysfunction of Alzheimer rats. 60 specific pathogen-free (SPF) SD rats were selected as research subjects. The, the AD model was created by injecting Aβ1-42 into hippocampus CA1 region of AD rats using a microscopic syringe. Besides, Morris water maze test and Western blot were performed to detect the cognitive function, the levels of destination protein and active oxidation products in the brain of rats. Compared to the Sham group, the escape latency and the distance of the model group significantly increased (P < 0.05), and the number of times to pass the target quadrant was significantly reduced (P < 0.05); the expression levels of E2F-1 and NF-κB protein in the hippocampus and the phosphorylation levels of Tau231, Tau262, Tau396, Tau404 and T216-GSK-3β protein of the model group were significantly increased (P < 0.05); the ROS/RNS value in the hippocampus of the model group significantly increased (P < 0.05). AD model rats exhibit obvious cognitive dysfunction, which is associated with the activation of E2F-1/NF-κB/GSK-3β signaling pathway and the heightened Tau protein phosphorylation level.
format	article
author	Mayila Tuerxun Ajar Muhda Lixin Yin
author_facet	Mayila Tuerxun Ajar Muhda Lixin Yin
author_sort	Mayila Tuerxun
title	The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats
title_short	The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats
title_full	The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats
title_fullStr	The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats
title_full_unstemmed	The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats
title_sort	molecular mechanisms of signal pathway activating effect of e2f-1/nf-κb/gsk-3β on cognitive dysfunction of alzheimer rats
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/6e998041569946c7ad133b22a05cc7f2
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The molecular mechanisms of signal pathway activating effect of E2F-1/NF-κB/GSK-3β on cognitive dysfunction of Alzheimer rats

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