Dexamethasone increased the survival rate in Plasmodium berghei-infected mice

Abstract The present study aimed to evaluate the effects of dexamethasone on the redox status, parasitemia evolution, and survival rate of Plasmodium berghei-infected mice. Two-hundred and twenty-five mice were infected with Plasmodium berghei and subjected to stimulation or inhibition of NO synthes...

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Autores principales:	Danilo Reymão Moreira, Ana Carolina Musa Gonçalves Uberti, Antonio Rafael Quadros Gomes, Michelli Erica Souza Ferreira, Aline da Silva Barbosa, Everton Luiz Pompeu Varela, Maria Fani Dolabela, Sandro Percário
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6e9c9a22fb8d4bdbb657cdef28d91fec
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spelling	oai:doaj.org-article:6e9c9a22fb8d4bdbb657cdef28d91fec2021-12-02T10:48:22ZDexamethasone increased the survival rate in Plasmodium berghei-infected mice10.1038/s41598-021-82032-72045-2322https://doaj.org/article/6e9c9a22fb8d4bdbb657cdef28d91fec2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82032-7https://doaj.org/toc/2045-2322Abstract The present study aimed to evaluate the effects of dexamethasone on the redox status, parasitemia evolution, and survival rate of Plasmodium berghei-infected mice. Two-hundred and twenty-five mice were infected with Plasmodium berghei and subjected to stimulation or inhibition of NO synthesis. The stimulation of NO synthesis was performed through the administration of L-arginine, while its inhibition was made by the administration of dexamethasone. Inducible NO synthase (iNOS) inhibition by dexamethasone promoted an increase in the survival rate of P. berghei-infected mice, and the data suggested the participation of oxidative stress in the brain as a result of plasmodial infection, as well as the inhibition of brain NO synthesis, which promoted the survival rate of almost 90% of the animals until the 15th day of infection, with possible direct interference of ischemia and reperfusion syndrome, as seen by increased levels of uric acid. Inhibition of brain iNOS by dexamethasone caused a decrease in parasitemia and increased the survival rate of infected animals, suggesting that NO synthesis may stimulate a series of compensatory redox effects that, if overstimulated, may be responsible for the onset of severe forms of malaria.Danilo Reymão MoreiraAna Carolina Musa Gonçalves UbertiAntonio Rafael Quadros GomesMichelli Erica Souza FerreiraAline da Silva BarbosaEverton Luiz Pompeu VarelaMaria Fani DolabelaSandro PercárioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danilo Reymão Moreira Ana Carolina Musa Gonçalves Uberti Antonio Rafael Quadros Gomes Michelli Erica Souza Ferreira Aline da Silva Barbosa Everton Luiz Pompeu Varela Maria Fani Dolabela Sandro Percário Dexamethasone increased the survival rate in Plasmodium berghei-infected mice
description	Abstract The present study aimed to evaluate the effects of dexamethasone on the redox status, parasitemia evolution, and survival rate of Plasmodium berghei-infected mice. Two-hundred and twenty-five mice were infected with Plasmodium berghei and subjected to stimulation or inhibition of NO synthesis. The stimulation of NO synthesis was performed through the administration of L-arginine, while its inhibition was made by the administration of dexamethasone. Inducible NO synthase (iNOS) inhibition by dexamethasone promoted an increase in the survival rate of P. berghei-infected mice, and the data suggested the participation of oxidative stress in the brain as a result of plasmodial infection, as well as the inhibition of brain NO synthesis, which promoted the survival rate of almost 90% of the animals until the 15th day of infection, with possible direct interference of ischemia and reperfusion syndrome, as seen by increased levels of uric acid. Inhibition of brain iNOS by dexamethasone caused a decrease in parasitemia and increased the survival rate of infected animals, suggesting that NO synthesis may stimulate a series of compensatory redox effects that, if overstimulated, may be responsible for the onset of severe forms of malaria.
format	article
author	Danilo Reymão Moreira Ana Carolina Musa Gonçalves Uberti Antonio Rafael Quadros Gomes Michelli Erica Souza Ferreira Aline da Silva Barbosa Everton Luiz Pompeu Varela Maria Fani Dolabela Sandro Percário
author_facet	Danilo Reymão Moreira Ana Carolina Musa Gonçalves Uberti Antonio Rafael Quadros Gomes Michelli Erica Souza Ferreira Aline da Silva Barbosa Everton Luiz Pompeu Varela Maria Fani Dolabela Sandro Percário
author_sort	Danilo Reymão Moreira
title	Dexamethasone increased the survival rate in Plasmodium berghei-infected mice
title_short	Dexamethasone increased the survival rate in Plasmodium berghei-infected mice
title_full	Dexamethasone increased the survival rate in Plasmodium berghei-infected mice
title_fullStr	Dexamethasone increased the survival rate in Plasmodium berghei-infected mice
title_full_unstemmed	Dexamethasone increased the survival rate in Plasmodium berghei-infected mice
title_sort	dexamethasone increased the survival rate in plasmodium berghei-infected mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6e9c9a22fb8d4bdbb657cdef28d91fec
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Dexamethasone increased the survival rate in Plasmodium berghei-infected mice

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