mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer

Extensive preclinical studies have identified mammalian target of rapamycin (mTOR) activation as a frequent molecular signature underlying head and neck squamous cell carcinoma (HNSCC), including the distinct clinical subtype that is human papillomavirus (HPV) related, and have demonstrated the pote...

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Autores principales:	Joseph D. Coppock, John H. Lee
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/6ea55a55dc194ba9983b051ef865fc79
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spelling	oai:doaj.org-article:6ea55a55dc194ba9983b051ef865fc792021-12-02T12:53:35ZmTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer2095-881110.1016/j.wjorl.2016.05.010https://doaj.org/article/6ea55a55dc194ba9983b051ef865fc792016-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116300154https://doaj.org/toc/2095-8811Extensive preclinical studies have identified mammalian target of rapamycin (mTOR) activation as a frequent molecular signature underlying head and neck squamous cell carcinoma (HNSCC), including the distinct clinical subtype that is human papillomavirus (HPV) related, and have demonstrated the potential therapeutic utility of mTOR inhibitors in the treatment of these cancers. Numerous clinical studies have begun to evaluate this potential, however few have selected for and fewer have focused specifically on HPV-related disease. While HPV-positive (HPV+) HNSCC patients have a generally favorable prognosis, the overall number of patients who suffer failed treatment, recurrent disease, metastasis, and death is increasing due to the rapidly increasing incidence of HPV-related cancers. In this review, we discuss the rationale for proposing the adjuvant use of mTOR inhibition in the treatment of HPV+ HNSCC, highlighting the interplay of virally activated mTOR signaling, cellular metabolism, and the anti-tumor immune response. Keywords: Head and neck oropharyngeal carcinoma, Human papillomavirus, Metabolism, mTOR, RapamycinJoseph D. CoppockJohn H. LeeKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 2, Iss 2, Pp 76-83 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Joseph D. Coppock John H. Lee mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
description	Extensive preclinical studies have identified mammalian target of rapamycin (mTOR) activation as a frequent molecular signature underlying head and neck squamous cell carcinoma (HNSCC), including the distinct clinical subtype that is human papillomavirus (HPV) related, and have demonstrated the potential therapeutic utility of mTOR inhibitors in the treatment of these cancers. Numerous clinical studies have begun to evaluate this potential, however few have selected for and fewer have focused specifically on HPV-related disease. While HPV-positive (HPV+) HNSCC patients have a generally favorable prognosis, the overall number of patients who suffer failed treatment, recurrent disease, metastasis, and death is increasing due to the rapidly increasing incidence of HPV-related cancers. In this review, we discuss the rationale for proposing the adjuvant use of mTOR inhibition in the treatment of HPV+ HNSCC, highlighting the interplay of virally activated mTOR signaling, cellular metabolism, and the anti-tumor immune response. Keywords: Head and neck oropharyngeal carcinoma, Human papillomavirus, Metabolism, mTOR, Rapamycin
format	article
author	Joseph D. Coppock John H. Lee
author_facet	Joseph D. Coppock John H. Lee
author_sort	Joseph D. Coppock
title	mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
title_short	mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
title_full	mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
title_fullStr	mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
title_full_unstemmed	mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
title_sort	mtor, metabolism, and the immune response in hpv-positive head and neck squamous cell cancer
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/6ea55a55dc194ba9983b051ef865fc79
work_keys_str_mv	AT josephdcoppock mtormetabolismandtheimmuneresponseinhpvpositiveheadandnecksquamouscellcancer AT johnhlee mtormetabolismandtheimmuneresponseinhpvpositiveheadandnecksquamouscellcancer
_version_	1718393570627420160

mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer

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