CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?

Cancer metastasis and recurrence are the leading causes of cancer-related death. Tumor cells which leave the primary or secondary tumors and shed into the bloodstream are called circulating tumor cells (CTC). These cells are the key drivers of cancer dissemination to surrounding tissues and to dista...

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Autores principales:	I. Kryvoshlyk, L. Skivka
Formato:	article
Lenguaje:	EN RU UK
Publicado:	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2021
Materias:	circulating tumor cells circulating tumor microembols metastasis epithelial mesenchymal transition minimal residual disease. Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/6ea5f877bf924f7a8a4be1950fd9e9f7
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spelling	oai:doaj.org-article:6ea5f877bf924f7a8a4be1950fd9e9f72021-11-03T17:12:27ZCIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?2410-77512410-776Xhttps://doaj.org/article/6ea5f877bf924f7a8a4be1950fd9e9f72021-08-01T00:00:00Zhttp://biotechnology.kiev.ua/images/4_2021/kryvoshlyk_4_2021.pdfhttps://doaj.org/toc/2410-7751https://doaj.org/toc/2410-776XCancer metastasis and recurrence are the leading causes of cancer-related death. Tumor cells which leave the primary or secondary tumors and shed into the bloodstream are called circulating tumor cells (CTC). These cells are the key drivers of cancer dissemination to surrounding tissues and to distant organs. The use of CTC in clinical practice necessitates the deep insight into their biology, as well as into their role in cancer evasion of immune surveillance, tumor resistance to chemo- radio- and immunotherapies and metastatic dormancy. Aim. The purpose of the work was to review the current knowledge on the CTC biology, as well as the prospects for their use for the diagnosis and targeted treatment of metastatic disease. Methods. The work proposed the integrative literature review using MEDLINE, Biological Abstracts and EMBASE databases. Results. This review summarizes and discusses historical milestones and current data concerning СTС biology, the main stages of their life cycle, their role in metastatic cascade, clinical prospects for their use as markers for the diagnosis and prognostication of the disease course, as well as targets for cancer treatment. Conclusions. Significant progress in the area of CTC biology and their use in cancer theranostics convincingly proved the attractiveness of these cells as targets for cancer prognosis and therapy. The effective use of liquid biopsy with quantitative and phenotypic characteristics of CTCs is impeded by the imperfection of the methodology for taking biological material and by the lack of reliable markers for assessing the metastatic potential of CTCs of various origins. The variety of mechanisms of tumor cells migration and invasion requires the development of complex therapeutic approaches for anti-metastatic therapy targeting CTCs. Efforts to address these key issues could help developing new and effective cancer treatment strategies.I. KryvoshlykL. SkivkaNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.articlecirculating tumor cellscirculating tumor microembolsmetastasisepithelial mesenchymal transitionminimal residual disease.BiotechnologyTP248.13-248.65ENRUUKBiotechnologia Acta, Vol 14, Iss 4, Pp 5-27 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	circulating tumor cells circulating tumor microembols metastasis epithelial mesenchymal transition minimal residual disease. Biotechnology TP248.13-248.65
spellingShingle	circulating tumor cells circulating tumor microembols metastasis epithelial mesenchymal transition minimal residual disease. Biotechnology TP248.13-248.65 I. Kryvoshlyk L. Skivka CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?
description	Cancer metastasis and recurrence are the leading causes of cancer-related death. Tumor cells which leave the primary or secondary tumors and shed into the bloodstream are called circulating tumor cells (CTC). These cells are the key drivers of cancer dissemination to surrounding tissues and to distant organs. The use of CTC in clinical practice necessitates the deep insight into their biology, as well as into their role in cancer evasion of immune surveillance, tumor resistance to chemo- radio- and immunotherapies and metastatic dormancy. Aim. The purpose of the work was to review the current knowledge on the CTC biology, as well as the prospects for their use for the diagnosis and targeted treatment of metastatic disease. Methods. The work proposed the integrative literature review using MEDLINE, Biological Abstracts and EMBASE databases. Results. This review summarizes and discusses historical milestones and current data concerning СTС biology, the main stages of their life cycle, their role in metastatic cascade, clinical prospects for their use as markers for the diagnosis and prognostication of the disease course, as well as targets for cancer treatment. Conclusions. Significant progress in the area of CTC biology and their use in cancer theranostics convincingly proved the attractiveness of these cells as targets for cancer prognosis and therapy. The effective use of liquid biopsy with quantitative and phenotypic characteristics of CTCs is impeded by the imperfection of the methodology for taking biological material and by the lack of reliable markers for assessing the metastatic potential of CTCs of various origins. The variety of mechanisms of tumor cells migration and invasion requires the development of complex therapeutic approaches for anti-metastatic therapy targeting CTCs. Efforts to address these key issues could help developing new and effective cancer treatment strategies.
format	article
author	I. Kryvoshlyk L. Skivka
author_facet	I. Kryvoshlyk L. Skivka
author_sort	I. Kryvoshlyk
title	CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?
title_short	CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?
title_full	CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?
title_fullStr	CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?
title_full_unstemmed	CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?
title_sort	circulating tumor cells: where we left off?
publisher	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
publishDate	2021
url	https://doaj.org/article/6ea5f877bf924f7a8a4be1950fd9e9f7
work_keys_str_mv	AT ikryvoshlyk circulatingtumorcellswhereweleftoff AT lskivka circulatingtumorcellswhereweleftoff
_version_	1718445519355772928

CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?

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