Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

Tumour metastasis is dependent on tumour cell motility. Here, the authors investigate genes required for tumour cell motility by establishing a quantitative in vivo screening platform based on intravital imaging of human cancer metastasis in ex ovo avian embryos.

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Autores principales:	Konstantin Stoletov, Lian Willetts, Robert J. Paproski, David J. Bond, Srijan Raha, Juan Jovel, Benjamin Adam, Amy E. Robertson, Francis Wong, Emma Woolner, Deborah L. Sosnowski, Tarek A. Bismar, Gane Ka-Shu Wong, Andries Zijlstra, John D. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6eaaead183094b5f8bd43f326a603694
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spelling	oai:doaj.org-article:6eaaead183094b5f8bd43f326a6036942021-12-02T13:23:48ZQuantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis10.1038/s41467-018-04743-22041-1723https://doaj.org/article/6eaaead183094b5f8bd43f326a6036942018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04743-2https://doaj.org/toc/2041-1723Tumour metastasis is dependent on tumour cell motility. Here, the authors investigate genes required for tumour cell motility by establishing a quantitative in vivo screening platform based on intravital imaging of human cancer metastasis in ex ovo avian embryos.Konstantin StoletovLian WillettsRobert J. PaproskiDavid J. BondSrijan RahaJuan JovelBenjamin AdamAmy E. RobertsonFrancis WongEmma WoolnerDeborah L. SosnowskiTarek A. BismarGane Ka-Shu WongAndries ZijlstraJohn D. LewisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Konstantin Stoletov Lian Willetts Robert J. Paproski David J. Bond Srijan Raha Juan Jovel Benjamin Adam Amy E. Robertson Francis Wong Emma Woolner Deborah L. Sosnowski Tarek A. Bismar Gane Ka-Shu Wong Andries Zijlstra John D. Lewis Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis
description	Tumour metastasis is dependent on tumour cell motility. Here, the authors investigate genes required for tumour cell motility by establishing a quantitative in vivo screening platform based on intravital imaging of human cancer metastasis in ex ovo avian embryos.
format	article
author	Konstantin Stoletov Lian Willetts Robert J. Paproski David J. Bond Srijan Raha Juan Jovel Benjamin Adam Amy E. Robertson Francis Wong Emma Woolner Deborah L. Sosnowski Tarek A. Bismar Gane Ka-Shu Wong Andries Zijlstra John D. Lewis
author_facet	Konstantin Stoletov Lian Willetts Robert J. Paproski David J. Bond Srijan Raha Juan Jovel Benjamin Adam Amy E. Robertson Francis Wong Emma Woolner Deborah L. Sosnowski Tarek A. Bismar Gane Ka-Shu Wong Andries Zijlstra John D. Lewis
author_sort	Konstantin Stoletov
title	Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis
title_short	Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis
title_full	Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis
title_fullStr	Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis
title_full_unstemmed	Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis
title_sort	quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6eaaead183094b5f8bd43f326a603694
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Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

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