Clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study

Clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study

Yong-Lin Liu,1 Wei-Min Xiao,1 Man-Qiu Liang,2 Zhi-Qiang Wu,1 Ya-Zhi Wang,1 Jian-Feng Qu,1 Yang-Kun Chen11Department of Neurology, Affiliated Dongguan People’s Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong Province, People’s Repu...

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Autores principales: Liu YL, Xiao WM, Liang MQ, Wu ZQ, Wang YZ, Qu JF, Chen YK
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Wernicke’s encephalopathy
altered mental status
magnetic resonance imaging
fasting
thiamine
alcoholism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/6eae6e2b05a14820b1bbca72190e6c9d
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spelling oai:doaj.org-article:6eae6e2b05a14820b1bbca72190e6c9d2021-12-02T11:05:47ZClinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study1178-2021https://doaj.org/article/6eae6e2b05a14820b1bbca72190e6c9d2019-08-01T00:00:00Zhttps://www.dovepress.com/clinical-characteristics-and-magnetic-resonance-imaging-findings-in-ni-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yong-Lin Liu,1 Wei-Min Xiao,1 Man-Qiu Liang,2 Zhi-Qiang Wu,1 Ya-Zhi Wang,1 Jian-Feng Qu,1 Yang-Kun Chen11Department of Neurology, Affiliated Dongguan People’s Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong Province, People’s Republic of China; 2Department of Radiology, Affiliated Dongguan People’s Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong Province, People’s Republic of ChinaCorrespondence: Yang-Kun ChenDepartment of Neurology, Affiliated Dongguan People’s Hospital, Southern Medical University (Dongguan People’s Hospital), 3 South Wandao Road, Wanjiang District, Dongguan City, Guangdong Province 523059, People’s Republic of ChinaTel +86 7 692 863 6830Fax +86 07 692 222 2353Email cykun78@163.comPurpose: Wernicke’s encephalopathy (WE) is a severe neurological disorder caused by thiamine deficiency. The most common cause of WE is alcoholism. However, there is a significant paucity of information in the existing literature relating to nonalcoholic WE. In this study, we investigated the clinical characteristics and neuroimaging findings of nine patients with nonalcoholic WE.Patients and methods: We retrospectively collated clinical data from nine patients who had been diagnosed with WE in accordance with established criteria including age, gender, risk factors and clinical manifestations. We also collated initial hematological and neuroimaging findings.Results: The mean age of the nine patients was 54.0±17.1 years; four of these patients (44.4%) were male. All nine patients had a history of fasting (range, 5–47 days) prior to WE. Four of the nine patients (44.4%) exhibited the classical triad, and eight (88.9%) showed alterations in mental status. Magnetic resonance imaging (MRI) scans showed that all nine patients had symmetric lesions of the medial thalamus. MRI also revealed other WE-related lesions in mammillary bodies (22.2%), the periaqueductal region (55.6%), the tectal plate of the midbrain (77.8%), cranial nerve nuclei (77.8%) and in the symmetric subcortical white matter (11.1%).Conclusion: Our analysis showed that fasting is a common cause of WE in nonalcoholic patients and that MRI is a useful tool for the diagnosis of WE. The most common MRI findings were symmetrical lesions of the medial thalamus lesions, followed by the tectal plate of the midbrain and cranial nerve nuclei.Keywords: Wernicke’s encephalopathy, altered mental status, magnetic resonance imaging, fasting, thiamine, alcoholismLiu YLXiao WMLiang MQWu ZQWang YZQu JFChen YKDove Medical PressarticleWernicke’s encephalopathyaltered mental statusmagnetic resonance imagingfastingthiaminealcoholismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2433-2441 (2019)
institution DOAJ
collection DOAJ
language EN
topic Wernicke’s encephalopathy
altered mental status
magnetic resonance imaging
fasting
thiamine
alcoholism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Wernicke’s encephalopathy
altered mental status
magnetic resonance imaging
fasting
thiamine
alcoholism
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Liu YL
Xiao WM
Liang MQ
Wu ZQ
Wang YZ
Qu JF
Chen YK
Clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study
description Yong-Lin Liu,1 Wei-Min Xiao,1 Man-Qiu Liang,2 Zhi-Qiang Wu,1 Ya-Zhi Wang,1 Jian-Feng Qu,1 Yang-Kun Chen11Department of Neurology, Affiliated Dongguan People’s Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong Province, People’s Republic of China; 2Department of Radiology, Affiliated Dongguan People’s Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, Guangdong Province, People’s Republic of ChinaCorrespondence: Yang-Kun ChenDepartment of Neurology, Affiliated Dongguan People’s Hospital, Southern Medical University (Dongguan People’s Hospital), 3 South Wandao Road, Wanjiang District, Dongguan City, Guangdong Province 523059, People’s Republic of ChinaTel +86 7 692 863 6830Fax +86 07 692 222 2353Email cykun78@163.comPurpose: Wernicke’s encephalopathy (WE) is a severe neurological disorder caused by thiamine deficiency. The most common cause of WE is alcoholism. However, there is a significant paucity of information in the existing literature relating to nonalcoholic WE. In this study, we investigated the clinical characteristics and neuroimaging findings of nine patients with nonalcoholic WE.Patients and methods: We retrospectively collated clinical data from nine patients who had been diagnosed with WE in accordance with established criteria including age, gender, risk factors and clinical manifestations. We also collated initial hematological and neuroimaging findings.Results: The mean age of the nine patients was 54.0±17.1 years; four of these patients (44.4%) were male. All nine patients had a history of fasting (range, 5–47 days) prior to WE. Four of the nine patients (44.4%) exhibited the classical triad, and eight (88.9%) showed alterations in mental status. Magnetic resonance imaging (MRI) scans showed that all nine patients had symmetric lesions of the medial thalamus. MRI also revealed other WE-related lesions in mammillary bodies (22.2%), the periaqueductal region (55.6%), the tectal plate of the midbrain (77.8%), cranial nerve nuclei (77.8%) and in the symmetric subcortical white matter (11.1%).Conclusion: Our analysis showed that fasting is a common cause of WE in nonalcoholic patients and that MRI is a useful tool for the diagnosis of WE. The most common MRI findings were symmetrical lesions of the medial thalamus lesions, followed by the tectal plate of the midbrain and cranial nerve nuclei.Keywords: Wernicke’s encephalopathy, altered mental status, magnetic resonance imaging, fasting, thiamine, alcoholism
format article
author Liu YL
Xiao WM
Liang MQ
Wu ZQ
Wang YZ
Qu JF
Chen YK
author_facet Liu YL
Xiao WM
Liang MQ
Wu ZQ
Wang YZ
Qu JF
Chen YK
author_sort Liu YL
title Clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study
title_short Clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study
title_full Clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study
title_fullStr Clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study
title_full_unstemmed Clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic Wernicke’s encephalopathy: a retrospective study
title_sort clinical characteristics and magnetic resonance imaging findings in nine patients with nonalcoholic wernicke’s encephalopathy: a retrospective study
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/6eae6e2b05a14820b1bbca72190e6c9d
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