Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase
Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans. Here the authors provide insights into FUT8 substrate recogn...
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Nature Portfolio
2020
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oai:doaj.org-article:6eaef7c9348f45cc8e916ae6a380340a2021-12-02T16:49:14ZStructural basis for substrate specificity and catalysis of α1,6-fucosyltransferase10.1038/s41467-020-14794-z2041-1723https://doaj.org/article/6eaef7c9348f45cc8e916ae6a380340a2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14794-zhttps://doaj.org/toc/2041-1723Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans. Here the authors provide insights into FUT8 substrate recognition by determining the 1.95 Å crystal structure of human FUT8 complexed with GDP and a biantennary complex N-glycan.Ana García-GarcíaLaura Ceballos-LaitaSonia SernaRaik ArtschwagerNiels C. ReichardtFrancisco CorzanaRamon Hurtado-GuerreroNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
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Science Q Ana García-García Laura Ceballos-Laita Sonia Serna Raik Artschwager Niels C. Reichardt Francisco Corzana Ramon Hurtado-Guerrero Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase |
description |
Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans. Here the authors provide insights into FUT8 substrate recognition by determining the 1.95 Å crystal structure of human FUT8 complexed with GDP and a biantennary complex N-glycan. |
format |
article |
author |
Ana García-García Laura Ceballos-Laita Sonia Serna Raik Artschwager Niels C. Reichardt Francisco Corzana Ramon Hurtado-Guerrero |
author_facet |
Ana García-García Laura Ceballos-Laita Sonia Serna Raik Artschwager Niels C. Reichardt Francisco Corzana Ramon Hurtado-Guerrero |
author_sort |
Ana García-García |
title |
Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase |
title_short |
Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase |
title_full |
Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase |
title_fullStr |
Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase |
title_full_unstemmed |
Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase |
title_sort |
structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/6eaef7c9348f45cc8e916ae6a380340a |
work_keys_str_mv |
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