Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.

<h4>Background</h4>Congenital heart defects (CHDs) are the most common congenital malformations. The aetiology of CHDs is complex. Large cohort studies and systematic reviews and meta-analyses based on these have reported an association between higher risk of CHDs in the offspring and in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gitte Hedermann, Paula L Hedley, Ida N Thagaard, Lone Krebs, Charlotte Kvist Ekelund, Thorkild I A Sørensen, Michael Christiansen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6eaf68dfdc08462a8f7badf0217b7e11
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6eaf68dfdc08462a8f7badf0217b7e11
record_format	dspace
spelling	oai:doaj.org-article:6eaf68dfdc08462a8f7badf0217b7e112021-11-25T06:23:41ZMaternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.1932-620310.1371/journal.pone.0252343https://doaj.org/article/6eaf68dfdc08462a8f7badf0217b7e112021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252343https://doaj.org/toc/1932-6203<h4>Background</h4>Congenital heart defects (CHDs) are the most common congenital malformations. The aetiology of CHDs is complex. Large cohort studies and systematic reviews and meta-analyses based on these have reported an association between higher risk of CHDs in the offspring and individual maternal metabolic disorders such as obesity, diabetes, hypertension, and preeclampsia, all conditions that can be related to insulin resistance or hyperglycaemia. However, the clinical reality is that these conditions often occur simultaneously. The aim of this review is, in consequence, both to evaluate the existing evidence on the association between maternal metabolic disorders, defined as obesity, diabetes, hypertension, preeclampsia, dyslipidaemia and CHDs in the offspring, as well as the significance of combinations, such as metabolic syndrome, as risk factors.<h4>Methods</h4>A systematic literature search of papers published between January 1, 1990 and January 14, 2021 was conducted using PubMed and Embase. Studies were eligible if they were published in English and were case-control or cohort studies. The exposures of interest were maternal overweight or obesity, hypertension, preeclampsia, diabetes, dyslipidaemia, and/or metabolic syndrome, and the outcome of interest was CHDs in the offspring. Furthermore, the studies were included according to a quality assessment score.<h4>Results</h4>Of the 2,250 identified studies, 32 qualified for inclusion. All but one study investigated only the individual metabolic disorders. Some disorders (obesity, gestational diabetes, and hypertension) increased risk of CHDs marginally whereas pre-gestational diabetes and early-onset preeclampsia were strongly associated with CHDs, without consistent differences between CHD subtypes. A single study suggested a possible additive effect of maternal obesity and gestational diabetes.<h4>Conclusions</h4>Future studies of the role of aberrations of the glucose-insulin homeostasis in the common aetiology and mechanisms of metabolic disorders, present during pregnancy, and their association, both as single conditions and-particularly-in combination, with CHDs are needed.Gitte HedermannPaula L HedleyIda N ThagaardLone KrebsCharlotte Kvist EkelundThorkild I A SørensenMichael ChristiansenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0252343 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gitte Hedermann Paula L Hedley Ida N Thagaard Lone Krebs Charlotte Kvist Ekelund Thorkild I A Sørensen Michael Christiansen Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.
description	<h4>Background</h4>Congenital heart defects (CHDs) are the most common congenital malformations. The aetiology of CHDs is complex. Large cohort studies and systematic reviews and meta-analyses based on these have reported an association between higher risk of CHDs in the offspring and individual maternal metabolic disorders such as obesity, diabetes, hypertension, and preeclampsia, all conditions that can be related to insulin resistance or hyperglycaemia. However, the clinical reality is that these conditions often occur simultaneously. The aim of this review is, in consequence, both to evaluate the existing evidence on the association between maternal metabolic disorders, defined as obesity, diabetes, hypertension, preeclampsia, dyslipidaemia and CHDs in the offspring, as well as the significance of combinations, such as metabolic syndrome, as risk factors.<h4>Methods</h4>A systematic literature search of papers published between January 1, 1990 and January 14, 2021 was conducted using PubMed and Embase. Studies were eligible if they were published in English and were case-control or cohort studies. The exposures of interest were maternal overweight or obesity, hypertension, preeclampsia, diabetes, dyslipidaemia, and/or metabolic syndrome, and the outcome of interest was CHDs in the offspring. Furthermore, the studies were included according to a quality assessment score.<h4>Results</h4>Of the 2,250 identified studies, 32 qualified for inclusion. All but one study investigated only the individual metabolic disorders. Some disorders (obesity, gestational diabetes, and hypertension) increased risk of CHDs marginally whereas pre-gestational diabetes and early-onset preeclampsia were strongly associated with CHDs, without consistent differences between CHD subtypes. A single study suggested a possible additive effect of maternal obesity and gestational diabetes.<h4>Conclusions</h4>Future studies of the role of aberrations of the glucose-insulin homeostasis in the common aetiology and mechanisms of metabolic disorders, present during pregnancy, and their association, both as single conditions and-particularly-in combination, with CHDs are needed.
format	article
author	Gitte Hedermann Paula L Hedley Ida N Thagaard Lone Krebs Charlotte Kvist Ekelund Thorkild I A Sørensen Michael Christiansen
author_facet	Gitte Hedermann Paula L Hedley Ida N Thagaard Lone Krebs Charlotte Kvist Ekelund Thorkild I A Sørensen Michael Christiansen
author_sort	Gitte Hedermann
title	Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.
title_short	Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.
title_full	Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.
title_fullStr	Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.
title_full_unstemmed	Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.
title_sort	maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6eaf68dfdc08462a8f7badf0217b7e11
work_keys_str_mv	AT gittehedermann maternalobesityandmetabolicdisordersassociatewithcongenitalheartdefectsintheoffspringasystematicreview AT paulalhedley maternalobesityandmetabolicdisordersassociatewithcongenitalheartdefectsintheoffspringasystematicreview AT idanthagaard maternalobesityandmetabolicdisordersassociatewithcongenitalheartdefectsintheoffspringasystematicreview AT lonekrebs maternalobesityandmetabolicdisordersassociatewithcongenitalheartdefectsintheoffspringasystematicreview AT charlottekvistekelund maternalobesityandmetabolicdisordersassociatewithcongenitalheartdefectsintheoffspringasystematicreview AT thorkildiasørensen maternalobesityandmetabolicdisordersassociatewithcongenitalheartdefectsintheoffspringasystematicreview AT michaelchristiansen maternalobesityandmetabolicdisordersassociatewithcongenitalheartdefectsintheoffspringasystematicreview
_version_	1718413750244999168

Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review.

Ejemplares similares