Clopidogrel-Induced Interstitial Lung Disease: A Case Report

Jin An,1 Seung Hwan Lee,2 Boksoon Chang1 1Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea; 2Department of Neurosurgery, Stroke and Neurological Disorder Center, Kyung Hee Unive...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	An J, Lee SH, Chang B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	clopidogrel cerebral infarction interstitial lung disease drug-induced lung disease Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6eb35231aa8a4cd8bf3441b0c4644cc8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6eb35231aa8a4cd8bf3441b0c4644cc8
record_format	dspace
spelling	oai:doaj.org-article:6eb35231aa8a4cd8bf3441b0c4644cc82021-12-02T16:12:38ZClopidogrel-Induced Interstitial Lung Disease: A Case Report1178-203Xhttps://doaj.org/article/6eb35231aa8a4cd8bf3441b0c4644cc82021-07-01T00:00:00Zhttps://www.dovepress.com/clopidogrel-induced-interstitial-lung-disease-a-case-report-peer-reviewed-fulltext-article-TCRMhttps://doaj.org/toc/1178-203XJin An,1 Seung Hwan Lee,2 Boksoon Chang1 1Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea; 2Department of Neurosurgery, Stroke and Neurological Disorder Center, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaCorrespondence: Boksoon ChangDepartment of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278, KoreaTel +82-2-440-6081Fax +82-2-440-8150Email meera.chang@gmail.comAbstract: In patients, with cerebral infarction resulting from intracranial arterial stenosis, the combined administration of clopidogrel and aspirin may be needed for to prevent subsequent ischemic attacks. Clopidogrel has an inevitable adverse effect profile, and the most common complications are related to hemorrhagic propensity. A 79-year-old female patient had used aspirin (100 mg/day) for cerebral infarction and then a dual antiplatelet regimen of aspirin and clopidogrel (75 mg/day) because of severe stenosis in both anterior cerebral arteries. Two weeks later, the patient presented with dyspnea started 3 days ago, which had worsened in the last 24 hours. Chest computed tomography on admission showed symmetric peribronchial ground-glass opacity with reticulation in both lungs. Microorganism tests, including serology and bronchoalveolar lavage for infection, were all negative. Clopidogrel was withdrawn because of suspected clopidogrel-induced interstitial lung disease, and steroid treatment was initiated. Clinical signs and chest radiographs improved after steroid treatment, and she was discharged on day 21 of admission. This case report shows that clopidogrel can induce interstitial lung disease as a rare complication and underscores the importance of recognizing this adverse effect in clinical practice.Keywords: clopidogrel, cerebral infarction, interstitial lung disease, drug-induced lung diseaseAn JLee SHChang BDove Medical Pressarticleclopidogrelcerebral infarctioninterstitial lung diseasedrug-induced lung diseaseTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 711-715 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clopidogrel cerebral infarction interstitial lung disease drug-induced lung disease Therapeutics. Pharmacology RM1-950
spellingShingle	clopidogrel cerebral infarction interstitial lung disease drug-induced lung disease Therapeutics. Pharmacology RM1-950 An J Lee SH Chang B Clopidogrel-Induced Interstitial Lung Disease: A Case Report
description	Jin An,1 Seung Hwan Lee,2 Boksoon Chang1 1Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea; 2Department of Neurosurgery, Stroke and Neurological Disorder Center, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of KoreaCorrespondence: Boksoon ChangDepartment of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, 05278, KoreaTel +82-2-440-6081Fax +82-2-440-8150Email meera.chang@gmail.comAbstract: In patients, with cerebral infarction resulting from intracranial arterial stenosis, the combined administration of clopidogrel and aspirin may be needed for to prevent subsequent ischemic attacks. Clopidogrel has an inevitable adverse effect profile, and the most common complications are related to hemorrhagic propensity. A 79-year-old female patient had used aspirin (100 mg/day) for cerebral infarction and then a dual antiplatelet regimen of aspirin and clopidogrel (75 mg/day) because of severe stenosis in both anterior cerebral arteries. Two weeks later, the patient presented with dyspnea started 3 days ago, which had worsened in the last 24 hours. Chest computed tomography on admission showed symmetric peribronchial ground-glass opacity with reticulation in both lungs. Microorganism tests, including serology and bronchoalveolar lavage for infection, were all negative. Clopidogrel was withdrawn because of suspected clopidogrel-induced interstitial lung disease, and steroid treatment was initiated. Clinical signs and chest radiographs improved after steroid treatment, and she was discharged on day 21 of admission. This case report shows that clopidogrel can induce interstitial lung disease as a rare complication and underscores the importance of recognizing this adverse effect in clinical practice.Keywords: clopidogrel, cerebral infarction, interstitial lung disease, drug-induced lung disease
format	article
author	An J Lee SH Chang B
author_facet	An J Lee SH Chang B
author_sort	An J
title	Clopidogrel-Induced Interstitial Lung Disease: A Case Report
title_short	Clopidogrel-Induced Interstitial Lung Disease: A Case Report
title_full	Clopidogrel-Induced Interstitial Lung Disease: A Case Report
title_fullStr	Clopidogrel-Induced Interstitial Lung Disease: A Case Report
title_full_unstemmed	Clopidogrel-Induced Interstitial Lung Disease: A Case Report
title_sort	clopidogrel-induced interstitial lung disease: a case report
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6eb35231aa8a4cd8bf3441b0c4644cc8
work_keys_str_mv	AT anj clopidogrelinducedinterstitiallungdiseaseacasereport AT leesh clopidogrelinducedinterstitiallungdiseaseacasereport AT changb clopidogrelinducedinterstitiallungdiseaseacasereport
_version_	1718384355598925824

Clopidogrel-Induced Interstitial Lung Disease: A Case Report

Ejemplares similares