Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression

Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression

Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2.

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Autores principales: Wei Xiang, Rongchen Shi, Xia Kang, Xuan Zhang, Peng Chen, Lili Zhang, Along Hou, Rui Wang, Yuanyin Zhao, Kun Zhao, Yingzhe Liu, Yue Ma, Huan Luo, Shenglan Shang, Jinyu Zhang, Fengtian He, Songtao Yu, Lixia Gan, Chunmeng Shi, Yongsheng Li, Wei Yang, Houjie Liang, Hongming Miao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/6eb51a074121441cbb4d93d358b47fe6
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spelling oai:doaj.org-article:6eb51a074121441cbb4d93d358b47fe62021-12-02T14:41:16ZMonoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression10.1038/s41467-018-04999-82041-1723https://doaj.org/article/6eb51a074121441cbb4d93d358b47fe62018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04999-8https://doaj.org/toc/2041-1723Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2.Wei XiangRongchen ShiXia KangXuan ZhangPeng ChenLili ZhangAlong HouRui WangYuanyin ZhaoKun ZhaoYingzhe LiuYue MaHuan LuoShenglan ShangJinyu ZhangFengtian HeSongtao YuLixia GanChunmeng ShiYongsheng LiWei YangHoujie LiangHongming MiaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wei Xiang
Rongchen Shi
Xia Kang
Xuan Zhang
Peng Chen
Lili Zhang
Along Hou
Rui Wang
Yuanyin Zhao
Kun Zhao
Yingzhe Liu
Yue Ma
Huan Luo
Shenglan Shang
Jinyu Zhang
Fengtian He
Songtao Yu
Lixia Gan
Chunmeng Shi
Yongsheng Li
Wei Yang
Houjie Liang
Hongming Miao
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
description Tumour associated macrophages (TAMs) have an altered lipid metabolism. Here the authors show that downregulation of monoacylglycerols lipase MGLL in TAMs induces lipid accumulation and tumor progression by polarizing TAMs toward tumor-promoting through activation of cannabinoid receptor CB2.
format article
author Wei Xiang
Rongchen Shi
Xia Kang
Xuan Zhang
Peng Chen
Lili Zhang
Along Hou
Rui Wang
Yuanyin Zhao
Kun Zhao
Yingzhe Liu
Yue Ma
Huan Luo
Shenglan Shang
Jinyu Zhang
Fengtian He
Songtao Yu
Lixia Gan
Chunmeng Shi
Yongsheng Li
Wei Yang
Houjie Liang
Hongming Miao
author_facet Wei Xiang
Rongchen Shi
Xia Kang
Xuan Zhang
Peng Chen
Lili Zhang
Along Hou
Rui Wang
Yuanyin Zhao
Kun Zhao
Yingzhe Liu
Yue Ma
Huan Luo
Shenglan Shang
Jinyu Zhang
Fengtian He
Songtao Yu
Lixia Gan
Chunmeng Shi
Yongsheng Li
Wei Yang
Houjie Liang
Hongming Miao
author_sort Wei Xiang
title Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
title_short Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
title_full Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
title_fullStr Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
title_full_unstemmed Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
title_sort monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6eb51a074121441cbb4d93d358b47fe6
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