A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling
Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which they use to dissect the role of the β-arrestin/...
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Nature Portfolio
2017
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oai:doaj.org-article:6eba6ba8e03a459fb317fb0b5ab084602021-12-02T14:40:56ZA new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling10.1038/ncomms150542041-1723https://doaj.org/article/6eba6ba8e03a459fb317fb0b5ab084602017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15054https://doaj.org/toc/2041-1723Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which they use to dissect the role of the β-arrestin/β2-adaptin interaction in GPCR signalling.Alexandre BeautraitJustine S. ParadisBrandon ZimmermanJenna GiubilaroLjiljana NikolajevSylvain ArmandoHiroyuki KobayashiLama YamaniYoon NamkungFranziska M. HeydenreichEtienne KhouryMartin AudetPhilippe P. RouxDmitry B. VeprintsevStéphane A. LaporteMichel BouvierNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Alexandre Beautrait Justine S. Paradis Brandon Zimmerman Jenna Giubilaro Ljiljana Nikolajev Sylvain Armando Hiroyuki Kobayashi Lama Yamani Yoon Namkung Franziska M. Heydenreich Etienne Khoury Martin Audet Philippe P. Roux Dmitry B. Veprintsev Stéphane A. Laporte Michel Bouvier A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling |
| description |
Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which they use to dissect the role of the β-arrestin/β2-adaptin interaction in GPCR signalling. |
| format |
article |
| author |
Alexandre Beautrait Justine S. Paradis Brandon Zimmerman Jenna Giubilaro Ljiljana Nikolajev Sylvain Armando Hiroyuki Kobayashi Lama Yamani Yoon Namkung Franziska M. Heydenreich Etienne Khoury Martin Audet Philippe P. Roux Dmitry B. Veprintsev Stéphane A. Laporte Michel Bouvier |
| author_facet |
Alexandre Beautrait Justine S. Paradis Brandon Zimmerman Jenna Giubilaro Ljiljana Nikolajev Sylvain Armando Hiroyuki Kobayashi Lama Yamani Yoon Namkung Franziska M. Heydenreich Etienne Khoury Martin Audet Philippe P. Roux Dmitry B. Veprintsev Stéphane A. Laporte Michel Bouvier |
| author_sort |
Alexandre Beautrait |
| title |
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling |
| title_short |
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling |
| title_full |
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling |
| title_fullStr |
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling |
| title_full_unstemmed |
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling |
| title_sort |
new inhibitor of the β-arrestin/ap2 endocytic complex reveals interplay between gpcr internalization and signalling |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6eba6ba8e03a459fb317fb0b5ab08460 |
| work_keys_str_mv |
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