Effect of alcohol consumption on kidney function: population-based cohort study

Abstract The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was...

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Autores principales:	Yu-Ji Lee, Seong Cho, Sung Rok Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ebc17e273ff4b4795cf6d2afc410dd4
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spelling	oai:doaj.org-article:6ebc17e273ff4b4795cf6d2afc410dd42021-12-02T13:57:26ZEffect of alcohol consumption on kidney function: population-based cohort study10.1038/s41598-021-81777-52045-2322https://doaj.org/article/6ebc17e273ff4b4795cf6d2afc410dd42021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81777-5https://doaj.org/toc/2045-2322Abstract The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was part of the Korean Genome and Epidemiology Study. Primary exposure was total alcohol intake (non-drinkers, 0 to < 10 g/day, 10 to < 30 g/day, and ≥ 30 g/day). Main outcome was decline in kidney function over 12 years. Our study included 5729 participants (mean [SD] age, 51 [8] years; 46% males). Compared to non-drinkers, higher alcohol intake groups had lesser reduction in estimated glomerular filtration rate (eGFR) over 12 years; fully adjusted beta coefficients and 95% confidence intervals were 0.45 (− 0.27, 1.18), 1.87 (0.88, 2.87), and 3.08 (1.93, 4.24) for participants with alcohol intake of < 10, 10 to < 30, and ≥ 30 g/day, respectively. However, this association was attenuated among women, smoker, and age ≥ 60 year. Compared with not drinking, more frequent alcohol consumption and binge drinking were associated with lesser reduction in eGFR. Our findings suggest that alcohol consumption may have a favorable effect on kidney function among the general population.Yu-Ji LeeSeong ChoSung Rok KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Ji Lee Seong Cho Sung Rok Kim Effect of alcohol consumption on kidney function: population-based cohort study
description	Abstract The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was part of the Korean Genome and Epidemiology Study. Primary exposure was total alcohol intake (non-drinkers, 0 to < 10 g/day, 10 to < 30 g/day, and ≥ 30 g/day). Main outcome was decline in kidney function over 12 years. Our study included 5729 participants (mean [SD] age, 51 [8] years; 46% males). Compared to non-drinkers, higher alcohol intake groups had lesser reduction in estimated glomerular filtration rate (eGFR) over 12 years; fully adjusted beta coefficients and 95% confidence intervals were 0.45 (− 0.27, 1.18), 1.87 (0.88, 2.87), and 3.08 (1.93, 4.24) for participants with alcohol intake of < 10, 10 to < 30, and ≥ 30 g/day, respectively. However, this association was attenuated among women, smoker, and age ≥ 60 year. Compared with not drinking, more frequent alcohol consumption and binge drinking were associated with lesser reduction in eGFR. Our findings suggest that alcohol consumption may have a favorable effect on kidney function among the general population.
format	article
author	Yu-Ji Lee Seong Cho Sung Rok Kim
author_facet	Yu-Ji Lee Seong Cho Sung Rok Kim
author_sort	Yu-Ji Lee
title	Effect of alcohol consumption on kidney function: population-based cohort study
title_short	Effect of alcohol consumption on kidney function: population-based cohort study
title_full	Effect of alcohol consumption on kidney function: population-based cohort study
title_fullStr	Effect of alcohol consumption on kidney function: population-based cohort study
title_full_unstemmed	Effect of alcohol consumption on kidney function: population-based cohort study
title_sort	effect of alcohol consumption on kidney function: population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6ebc17e273ff4b4795cf6d2afc410dd4
work_keys_str_mv	AT yujilee effectofalcoholconsumptiononkidneyfunctionpopulationbasedcohortstudy AT seongcho effectofalcoholconsumptiononkidneyfunctionpopulationbasedcohortstudy AT sungrokkim effectofalcoholconsumptiononkidneyfunctionpopulationbasedcohortstudy
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Effect of alcohol consumption on kidney function: population-based cohort study

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