The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients

Abstract Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects w...

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Autores principales:	Ju Lu, Miao Ma, Qi Zhao, Fanqing Meng, Dongmei Wang, Hourong Cai, Mengshu Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ec5de6aee62485c9bb38a6774fb66af
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spelling	oai:doaj.org-article:6ec5de6aee62485c9bb38a6774fb66af2021-12-02T11:40:16ZThe Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients10.1038/s41598-018-25670-82045-2322https://doaj.org/article/6ec5de6aee62485c9bb38a6774fb66af2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25670-8https://doaj.org/toc/2045-2322Abstract Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31–55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases. Five cases had underlying diseases, such as, Sjo¨gren’s syndrome, multi-centric castlemans’ disease, idiopathic pneumonia with autoimmune features and abscess. Five cases presented as interstitial lung disease (ILD) on chest imaging with centrilobular or peribronchiolar nodules, ground glass opacities, interlobular septal thickening, cysts and bronchiectasis. Isolated mass was in one patient. The histopathology suggested the changes of FB in all subjects. Prednisone and/or cyclophosphamide were used in four cases, one did the surgery and the other was clinically monitored. All cases were alive at the end of follow up. The adult patients of FB usually have mild symptoms, ILD and underlying diseases. The definite diagnosis needs SLB. The prognosis is depended on their underlying conditions.Ju LuMiao MaQi ZhaoFanqing MengDongmei WangHourong CaiMengshu CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ju Lu Miao Ma Qi Zhao Fanqing Meng Dongmei Wang Hourong Cai Mengshu Cao The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients
description	Abstract Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31–55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases. Five cases had underlying diseases, such as, Sjo¨gren’s syndrome, multi-centric castlemans’ disease, idiopathic pneumonia with autoimmune features and abscess. Five cases presented as interstitial lung disease (ILD) on chest imaging with centrilobular or peribronchiolar nodules, ground glass opacities, interlobular septal thickening, cysts and bronchiectasis. Isolated mass was in one patient. The histopathology suggested the changes of FB in all subjects. Prednisone and/or cyclophosphamide were used in four cases, one did the surgery and the other was clinically monitored. All cases were alive at the end of follow up. The adult patients of FB usually have mild symptoms, ILD and underlying diseases. The definite diagnosis needs SLB. The prognosis is depended on their underlying conditions.
format	article
author	Ju Lu Miao Ma Qi Zhao Fanqing Meng Dongmei Wang Hourong Cai Mengshu Cao
author_facet	Ju Lu Miao Ma Qi Zhao Fanqing Meng Dongmei Wang Hourong Cai Mengshu Cao
author_sort	Ju Lu
title	The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients
title_short	The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients
title_full	The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients
title_fullStr	The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients
title_full_unstemmed	The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients
title_sort	clinical characteristics and outcomes of follicular bronchiolitis in chinese adult patients
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6ec5de6aee62485c9bb38a6774fb66af
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The Clinical Characteristics and Outcomes of Follicular Bronchiolitis in Chinese Adult Patients

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