How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.

Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception -defined as the cognitive processing of body signals- has been extensively considered as a key processing for body self-awareness. In consequence, the purpose of this study was to...

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Autores principales:	Lucas Sedeño, Blas Couto, Margherita Melloni, Andrés Canales-Johnson, Adrián Yoris, Sandra Baez, Sol Esteves, Marcela Velásquez, Pablo Barttfeld, Mariano Sigman, Rafael Kichic, Dante Chialvo, Facundo Manes, Tristan A Bekinschtein, Agustin Ibanez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ec67f03dd1941889927dff15150aea3
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spelling	oai:doaj.org-article:6ec67f03dd1941889927dff15150aea32021-11-11T08:21:29ZHow do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.1932-620310.1371/journal.pone.0098769https://doaj.org/article/6ec67f03dd1941889927dff15150aea32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24967634/?tool=EBIhttps://doaj.org/toc/1932-6203Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception -defined as the cognitive processing of body signals- has been extensively considered as a key processing for body self-awareness. In consequence, the purpose of this study was to investigate whether there are systematic differences in interoception between a patient with DD and controls that might explain the disembodiment symptoms suffered in this disease. To assess interoception, we utilized a heartbeat detection task and measures of functional connectivity derived from fMRI networks in interoceptive/exteroceptivo/mind-wandering states. Additionally, we evaluated empathic abilities to test the association between interoception and emotional experience. The results showed patient's impaired performance in the heartbeat detection task when compared to controls. Furthermore, regarding functional connectivity, we found a lower global brain connectivity of the patient relative to controls only in the interoceptive state. He also presented a particular pattern of impairments in affective empathy. To our knowledge, this is the first experimental research that assesses the relationship between interoception and DD combining behavioral and neurobiological measures. Our results suggest that altered neural mechanisms and cognitive processes regarding body signaling might be engaged in DD phenomenology. Moreover, our study contributes experimental data to the comprehension of brain-body interactions and the emergence of self-awareness and emotional feelings.Lucas SedeñoBlas CoutoMargherita MelloniAndrés Canales-JohnsonAdrián YorisSandra BaezSol EstevesMarcela VelásquezPablo BarttfeldMariano SigmanRafael KichicDante ChialvoFacundo ManesTristan A BekinschteinAgustin IbanezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98769 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lucas Sedeño Blas Couto Margherita Melloni Andrés Canales-Johnson Adrián Yoris Sandra Baez Sol Esteves Marcela Velásquez Pablo Barttfeld Mariano Sigman Rafael Kichic Dante Chialvo Facundo Manes Tristan A Bekinschtein Agustin Ibanez How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.
description	Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception -defined as the cognitive processing of body signals- has been extensively considered as a key processing for body self-awareness. In consequence, the purpose of this study was to investigate whether there are systematic differences in interoception between a patient with DD and controls that might explain the disembodiment symptoms suffered in this disease. To assess interoception, we utilized a heartbeat detection task and measures of functional connectivity derived from fMRI networks in interoceptive/exteroceptivo/mind-wandering states. Additionally, we evaluated empathic abilities to test the association between interoception and emotional experience. The results showed patient's impaired performance in the heartbeat detection task when compared to controls. Furthermore, regarding functional connectivity, we found a lower global brain connectivity of the patient relative to controls only in the interoceptive state. He also presented a particular pattern of impairments in affective empathy. To our knowledge, this is the first experimental research that assesses the relationship between interoception and DD combining behavioral and neurobiological measures. Our results suggest that altered neural mechanisms and cognitive processes regarding body signaling might be engaged in DD phenomenology. Moreover, our study contributes experimental data to the comprehension of brain-body interactions and the emergence of self-awareness and emotional feelings.
format	article
author	Lucas Sedeño Blas Couto Margherita Melloni Andrés Canales-Johnson Adrián Yoris Sandra Baez Sol Esteves Marcela Velásquez Pablo Barttfeld Mariano Sigman Rafael Kichic Dante Chialvo Facundo Manes Tristan A Bekinschtein Agustin Ibanez
author_facet	Lucas Sedeño Blas Couto Margherita Melloni Andrés Canales-Johnson Adrián Yoris Sandra Baez Sol Esteves Marcela Velásquez Pablo Barttfeld Mariano Sigman Rafael Kichic Dante Chialvo Facundo Manes Tristan A Bekinschtein Agustin Ibanez
author_sort	Lucas Sedeño
title	How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.
title_short	How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.
title_full	How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.
title_fullStr	How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.
title_full_unstemmed	How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.
title_sort	how do you feel when you can't feel your body? interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6ec67f03dd1941889927dff15150aea3
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How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder.

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