Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.

Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.

Viruses have evolved elaborate mechanisms to evade or inactivate the complex system of sensors and signaling molecules that make up the host innate immune response. Here we show that human coronavirus (HCoV) NL63 and severe acute respiratory syndrome (SARS) CoV papain-like proteases (PLP) antagonize...

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Autores principales: Li Sun, Yaling Xing, Xiaojuan Chen, Yang Zheng, Yudong Yang, Daniel B Nichols, Mark A Clementz, Bridget S Banach, Kui Li, Susan C Baker, Zhongbin Chen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6ec96f38e90e415097ec935050eb3d82
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