Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin

Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated cell migration that drives extensive scar format...

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Autores principales:	Dongsheng Jiang, Simon Christ, Donovan Correa-Gallegos, Pushkar Ramesh, Shruthi Kalgudde Gopal, Juliane Wannemacher, Christoph H. Mayr, Valerio Lupperger, Qing Yu, Haifeng Ye, Martin Mück-Häusl, Vijayanand Rajendran, Li Wan, Juan Liu, Ursula Mirastschijski, Thomas Volz, Carsten Marr, Herbert B. Schiller, Yuval Rinkevich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6eca455309404024a7a128b6fcc9370e
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spelling	oai:doaj.org-article:6eca455309404024a7a128b6fcc9370e2021-12-02T16:56:31ZInjury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin10.1038/s41467-020-19425-12041-1723https://doaj.org/article/6eca455309404024a7a128b6fcc9370e2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19425-1https://doaj.org/toc/2041-1723Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated cell migration that drives extensive scar formation of deep wounds.Dongsheng JiangSimon ChristDonovan Correa-GallegosPushkar RameshShruthi Kalgudde GopalJuliane WannemacherChristoph H. MayrValerio LuppergerQing YuHaifeng YeMartin Mück-HäuslVijayanand RajendranLi WanJuan LiuUrsula MirastschijskiThomas VolzCarsten MarrHerbert B. SchillerYuval RinkevichNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dongsheng Jiang Simon Christ Donovan Correa-Gallegos Pushkar Ramesh Shruthi Kalgudde Gopal Juliane Wannemacher Christoph H. Mayr Valerio Lupperger Qing Yu Haifeng Ye Martin Mück-Häusl Vijayanand Rajendran Li Wan Juan Liu Ursula Mirastschijski Thomas Volz Carsten Marr Herbert B. Schiller Yuval Rinkevich Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin
description	Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated cell migration that drives extensive scar formation of deep wounds.
format	article
author	Dongsheng Jiang Simon Christ Donovan Correa-Gallegos Pushkar Ramesh Shruthi Kalgudde Gopal Juliane Wannemacher Christoph H. Mayr Valerio Lupperger Qing Yu Haifeng Ye Martin Mück-Häusl Vijayanand Rajendran Li Wan Juan Liu Ursula Mirastschijski Thomas Volz Carsten Marr Herbert B. Schiller Yuval Rinkevich
author_facet	Dongsheng Jiang Simon Christ Donovan Correa-Gallegos Pushkar Ramesh Shruthi Kalgudde Gopal Juliane Wannemacher Christoph H. Mayr Valerio Lupperger Qing Yu Haifeng Ye Martin Mück-Häusl Vijayanand Rajendran Li Wan Juan Liu Ursula Mirastschijski Thomas Volz Carsten Marr Herbert B. Schiller Yuval Rinkevich
author_sort	Dongsheng Jiang
title	Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin
title_short	Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin
title_full	Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin
title_fullStr	Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin
title_full_unstemmed	Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin
title_sort	injury triggers fascia fibroblast collective cell migration to drive scar formation through n-cadherin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6eca455309404024a7a128b6fcc9370e
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Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin

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