Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation
Grover’s disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like, spongiotic, and Hailey-Hailey-like. A case of a...
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oai:doaj.org-article:6ecab2e3c2244a188fd7a3571a6e2ee22021-11-17T08:30:36ZGrover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation10.5826/dpc.0703a112160-9381https://doaj.org/article/6ecab2e3c2244a188fd7a3571a6e2ee22017-08-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/323https://doaj.org/toc/2160-9381 Grover’s disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like, spongiotic, and Hailey-Hailey-like. A case of a 54-year-old female affected by Grover’s disease and showing a Darier-like histopathological pattern is described. Polarized light dermoscopy (PLD) revealed the presence of polygonal, star-like shaped yellowish/brownish areas of various sizes surrounded by a thin whitish halo. Handheld reflectance confocal microscopy (RCM) showed the presence of intraepidermal dark spaces histopathologically corresponding to intraepidermal clefts, roundish, bright cells correlating to acantholytic keratinocytes, target-like cells with a dark center and a highly reflectant halo corresponding to dyskeratotic cells, and epidermal, polygonal, structureless areas reflecting hyperparakeratosis. In conclusion, the use of PLD and RCM combined with clinical presentation, personal/family history, and genetic evaluation may be useful for the non-invasive diagnosis of Darier-like Grover’s disease. Francesco LacarrubbaSimona BoscagliaMaria Rita NascaRosario CaltabianoGiuseppe MicaliMattioli1885articlereflectance confocal microscopydermoscopyGrover’s diseaseDarier’s diseaseacantholysiscorp rondsDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 7, Iss 3 (2017) |
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DOAJ |
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reflectance confocal microscopy dermoscopy Grover’s disease Darier’s disease acantholysis corp ronds Dermatology RL1-803 |
| spellingShingle |
reflectance confocal microscopy dermoscopy Grover’s disease Darier’s disease acantholysis corp ronds Dermatology RL1-803 Francesco Lacarrubba Simona Boscaglia Maria Rita Nasca Rosario Caltabiano Giuseppe Micali Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| description |
Grover’s disease is a benign condition of unknown origin characterized clinically by an erythematous papulovesicular eruption and histopathologically by intraepidermal clefting and four different patterns of acantholysis: Darier-like, pemphigus-like, spongiotic, and Hailey-Hailey-like. A case of a 54-year-old female affected by Grover’s disease and showing a Darier-like histopathological pattern is described. Polarized light dermoscopy (PLD) revealed the presence of polygonal, star-like shaped yellowish/brownish areas of various sizes surrounded by a thin whitish halo. Handheld reflectance confocal microscopy (RCM) showed the presence of intraepidermal dark spaces histopathologically corresponding to intraepidermal clefts, roundish, bright cells correlating to acantholytic keratinocytes, target-like cells with a dark center and a highly reflectant halo corresponding to dyskeratotic cells, and epidermal, polygonal, structureless areas reflecting hyperparakeratosis. In conclusion, the use of PLD and RCM combined with clinical presentation, personal/family history, and genetic evaluation may be useful for the non-invasive diagnosis of Darier-like Grover’s disease.
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| format |
article |
| author |
Francesco Lacarrubba Simona Boscaglia Maria Rita Nasca Rosario Caltabiano Giuseppe Micali |
| author_facet |
Francesco Lacarrubba Simona Boscaglia Maria Rita Nasca Rosario Caltabiano Giuseppe Micali |
| author_sort |
Francesco Lacarrubba |
| title |
Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_short |
Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_full |
Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_fullStr |
Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_full_unstemmed |
Grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| title_sort |
grover's disease: dermoscopy, reflectance confocal microscopy, and histopathological correlation |
| publisher |
Mattioli1885 |
| publishDate |
2017 |
| url |
https://doaj.org/article/6ecab2e3c2244a188fd7a3571a6e2ee2 |
| work_keys_str_mv |
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| _version_ |
1718425742539227136 |