Regulation of Adaptive Tumor Immunity by Non-Coding RNAs

Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-codin...

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Autores principales:	Eleftheria Papaioannou, María del Pilar González-Molina, Ana M. Prieto-Muñoz, Laura Gámez-Reche, Alicia González-Martín
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tumor immunology non-coding RNAs microRNAs long non-coding RNAs cancer immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6ecda2189d324e51940a23ef0df72c33
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spelling	oai:doaj.org-article:6ecda2189d324e51940a23ef0df72c332021-11-25T17:02:10ZRegulation of Adaptive Tumor Immunity by Non-Coding RNAs10.3390/cancers132256512072-6694https://doaj.org/article/6ecda2189d324e51940a23ef0df72c332021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5651https://doaj.org/toc/2072-6694Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been identified as critical regulators of immune cell development and function, suggesting that they might play important roles in orchestrating immune responses against tumors. In this review, we summarize the scientific advances on the role of ncRNAs in regulating adaptive tumor immunity, and discuss their potential therapeutic value in the context of cancer immunotherapy.Eleftheria PapaioannouMaría del Pilar González-MolinaAna M. Prieto-MuñozLaura Gámez-RecheAlicia González-MartínMDPI AGarticletumor immunologynon-coding RNAsmicroRNAslong non-coding RNAscancer immunotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5651, p 5651 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor immunology non-coding RNAs microRNAs long non-coding RNAs cancer immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	tumor immunology non-coding RNAs microRNAs long non-coding RNAs cancer immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Eleftheria Papaioannou María del Pilar González-Molina Ana M. Prieto-Muñoz Laura Gámez-Reche Alicia González-Martín Regulation of Adaptive Tumor Immunity by Non-Coding RNAs
description	Cancer immunology research has mainly focused on the role of protein-coding genes in regulating immune responses to tumors. However, despite more than 70% of the human genome is transcribed, less than 2% encodes proteins. Many non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been identified as critical regulators of immune cell development and function, suggesting that they might play important roles in orchestrating immune responses against tumors. In this review, we summarize the scientific advances on the role of ncRNAs in regulating adaptive tumor immunity, and discuss their potential therapeutic value in the context of cancer immunotherapy.
format	article
author	Eleftheria Papaioannou María del Pilar González-Molina Ana M. Prieto-Muñoz Laura Gámez-Reche Alicia González-Martín
author_facet	Eleftheria Papaioannou María del Pilar González-Molina Ana M. Prieto-Muñoz Laura Gámez-Reche Alicia González-Martín
author_sort	Eleftheria Papaioannou
title	Regulation of Adaptive Tumor Immunity by Non-Coding RNAs
title_short	Regulation of Adaptive Tumor Immunity by Non-Coding RNAs
title_full	Regulation of Adaptive Tumor Immunity by Non-Coding RNAs
title_fullStr	Regulation of Adaptive Tumor Immunity by Non-Coding RNAs
title_full_unstemmed	Regulation of Adaptive Tumor Immunity by Non-Coding RNAs
title_sort	regulation of adaptive tumor immunity by non-coding rnas
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6ecda2189d324e51940a23ef0df72c33
work_keys_str_mv	AT eleftheriapapaioannou regulationofadaptivetumorimmunitybynoncodingrnas AT mariadelpilargonzalezmolina regulationofadaptivetumorimmunitybynoncodingrnas AT anamprietomunoz regulationofadaptivetumorimmunitybynoncodingrnas AT lauragamezreche regulationofadaptivetumorimmunitybynoncodingrnas AT aliciagonzalezmartin regulationofadaptivetumorimmunitybynoncodingrnas
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Regulation of Adaptive Tumor Immunity by Non-Coding RNAs

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