Osseous manifestations of sarcoidosis

Sarcoidosis is a systemic multisystem inflammatory disease of unknown etiology. The disease is characterized by formation of non-caseating granulomas. The most common presentation is bilateral hilar lymphadenopathy and lung infiltration, but the disease is very heterogeneous, with an unpredictable c...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autor principal: Eugeniusz Józef Kucharz
Formato: article
Lenguaje:EN
Publicado: Termedia Publishing House 2020
Materias:
R
Acceso en línea:https://doaj.org/article/6ed059fe1e254b50892059656602b3e0
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:6ed059fe1e254b50892059656602b3e0
record_format dspace
spelling oai:doaj.org-article:6ed059fe1e254b50892059656602b3e02021-12-02T19:19:24ZOsseous manifestations of sarcoidosis0034-62332084-983410.5114/reum.2020.95363https://doaj.org/article/6ed059fe1e254b50892059656602b3e02020-04-01T00:00:00Zhttps://www.termedia.pl/Osseous-manifestations-of-sarcoidosis,18,40678,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834Sarcoidosis is a systemic multisystem inflammatory disease of unknown etiology. The disease is characterized by formation of non-caseating granulomas. The most common presentation is bilateral hilar lymphadenopathy and lung infiltration, but the disease is very heterogeneous, with an unpredictable clinical course. Musculoskeletal manifestations are common. Bone involvement is less frequent, and usually occurs in patients with chronic multisystem course of the disease. They are most commonly found in the phalanges of hands and feet, and are usually bilateral. The skull, long bones, ribs, pelvis, and axial skeleton may also be affected. Osseous involvement may be asymptomatic but in some cases can cause a severe disability. Imaging techniques are important for diagnosis. Radiological investigations revealed sclerotic or destructive lesions (involving also joints), cystic and punched out lesions and cortical abnormalities. Biopsy is required for differential diagnosis with respect to malignancy. Treatment is a part of systemic therapy and is not needed in all cases. Glucocorticoids and TNF-a antagonists are used for management.Eugeniusz Józef KucharzTermedia Publishing Housearticlesarcoidosis bone skeletal manifestationsMedicineRENRheumatology, Vol 58, Iss 2, Pp 93-100 (2020)
institution DOAJ
collection DOAJ
language EN
topic sarcoidosis
bone
skeletal manifestations
Medicine
R
spellingShingle sarcoidosis
bone
skeletal manifestations
Medicine
R
Eugeniusz Józef Kucharz
Osseous manifestations of sarcoidosis
description Sarcoidosis is a systemic multisystem inflammatory disease of unknown etiology. The disease is characterized by formation of non-caseating granulomas. The most common presentation is bilateral hilar lymphadenopathy and lung infiltration, but the disease is very heterogeneous, with an unpredictable clinical course. Musculoskeletal manifestations are common. Bone involvement is less frequent, and usually occurs in patients with chronic multisystem course of the disease. They are most commonly found in the phalanges of hands and feet, and are usually bilateral. The skull, long bones, ribs, pelvis, and axial skeleton may also be affected. Osseous involvement may be asymptomatic but in some cases can cause a severe disability. Imaging techniques are important for diagnosis. Radiological investigations revealed sclerotic or destructive lesions (involving also joints), cystic and punched out lesions and cortical abnormalities. Biopsy is required for differential diagnosis with respect to malignancy. Treatment is a part of systemic therapy and is not needed in all cases. Glucocorticoids and TNF-a antagonists are used for management.
format article
author Eugeniusz Józef Kucharz
author_facet Eugeniusz Józef Kucharz
author_sort Eugeniusz Józef Kucharz
title Osseous manifestations of sarcoidosis
title_short Osseous manifestations of sarcoidosis
title_full Osseous manifestations of sarcoidosis
title_fullStr Osseous manifestations of sarcoidosis
title_full_unstemmed Osseous manifestations of sarcoidosis
title_sort osseous manifestations of sarcoidosis
publisher Termedia Publishing House
publishDate 2020
url https://doaj.org/article/6ed059fe1e254b50892059656602b3e0
work_keys_str_mv AT eugeniuszjozefkucharz osseousmanifestationsofsarcoidosis
_version_ 1718376857475219456