Role of influenza A virus NP acetylation on viral growth and replication

Role of influenza A virus NP acetylation on viral growth and replication

Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and viri...

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Autores principales: Sebastian Giese, Kevin Ciminski, Hardin Bolte, Étori Aguiar Moreira, Seema Lakdawala, Zehan Hu, Quinnlan David, Larissa Kolesnikova, Veronika Götz, Yongxu Zhao, Jörn Dengjel, Y. Eugene Chin, Ke Xu, Martin Schwemmle
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6ed0845914b74bd29b55b944319e9373
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spelling oai:doaj.org-article:6ed0845914b74bd29b55b944319e93732021-12-02T14:42:42ZRole of influenza A virus NP acetylation on viral growth and replication10.1038/s41467-017-01112-32041-1723https://doaj.org/article/6ed0845914b74bd29b55b944319e93732017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01112-3https://doaj.org/toc/2041-1723Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and virion release.Sebastian GieseKevin CiminskiHardin BolteÉtori Aguiar MoreiraSeema LakdawalaZehan HuQuinnlan DavidLarissa KolesnikovaVeronika GötzYongxu ZhaoJörn DengjelY. Eugene ChinKe XuMartin SchwemmleNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sebastian Giese
Kevin Ciminski
Hardin Bolte
Étori Aguiar Moreira
Seema Lakdawala
Zehan Hu
Quinnlan David
Larissa Kolesnikova
Veronika Götz
Yongxu Zhao
Jörn Dengjel
Y. Eugene Chin
Ke Xu
Martin Schwemmle
Role of influenza A virus NP acetylation on viral growth and replication
description Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and virion release.
format article
author Sebastian Giese
Kevin Ciminski
Hardin Bolte
Étori Aguiar Moreira
Seema Lakdawala
Zehan Hu
Quinnlan David
Larissa Kolesnikova
Veronika Götz
Yongxu Zhao
Jörn Dengjel
Y. Eugene Chin
Ke Xu
Martin Schwemmle
author_facet Sebastian Giese
Kevin Ciminski
Hardin Bolte
Étori Aguiar Moreira
Seema Lakdawala
Zehan Hu
Quinnlan David
Larissa Kolesnikova
Veronika Götz
Yongxu Zhao
Jörn Dengjel
Y. Eugene Chin
Ke Xu
Martin Schwemmle
author_sort Sebastian Giese
title Role of influenza A virus NP acetylation on viral growth and replication
title_short Role of influenza A virus NP acetylation on viral growth and replication
title_full Role of influenza A virus NP acetylation on viral growth and replication
title_fullStr Role of influenza A virus NP acetylation on viral growth and replication
title_full_unstemmed Role of influenza A virus NP acetylation on viral growth and replication
title_sort role of influenza a virus np acetylation on viral growth and replication
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/6ed0845914b74bd29b55b944319e9373
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