Enhanced CD4+ and CD8+ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses

Enhanced CD4+ and CD8+ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses

Abstract The notion that T cell insulitis increases as type 1 diabetes (T1D) develops is unsurprising, however, the quantitative analysis of CD4+ and CD8+ T cells within the islet mass is complex and limited with standard approaches. Optical microscopy is an important and widely used method to evalu...

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Autores principales: Alexander J. Dwyer, Jacob M. Ritz, Jason S. Mitchell, Tijana Martinov, Mohannad Alkhatib, Nubia Silva, Christopher G. Tucker, Brian T. Fife
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/6ed0acc70c384d58b92cd026ebe5a4ee
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