Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web

Abstract Microcosms containing DDT spiked-sediment, Tubifex tubifex and carp (Cyprinus carpio) were constructed to simulate a freshwater system. The accumulation, elimination and toxic effects of DDT (p,p’-DDT, o,p’-DDT), and its metabolites DDD (p,p’-DDD, o,p’-DDD) and DDE (p,p’-DDE, o,p’-DDE) were...

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Autores principales:	Shanshan Di, Ruiquan Liu, Zhongnan Tian, Cheng Cheng, Li Chen, Wenjun Zhang, Zhiqiang Zhou, Jinling Diao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ed26a645e664ee5aa8a1044a7daf5a6
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spelling	oai:doaj.org-article:6ed26a645e664ee5aa8a1044a7daf5a62021-12-02T12:32:43ZAssessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web10.1038/s41598-017-02612-42045-2322https://doaj.org/article/6ed26a645e664ee5aa8a1044a7daf5a62017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02612-4https://doaj.org/toc/2045-2322Abstract Microcosms containing DDT spiked-sediment, Tubifex tubifex and carp (Cyprinus carpio) were constructed to simulate a freshwater system. The accumulation, elimination and toxic effects of DDT (p,p’-DDT, o,p’-DDT), and its metabolites DDD (p,p’-DDD, o,p’-DDD) and DDE (p,p’-DDE, o,p’-DDE) were studied in T. tubifex and carp. Tissue/organ distributions of DDTs were also investigated in carp. The bioaccumulation and elimination of DDT differed in T. tubifex, carp and its tissues/organs. Unimodal or bimodal distributions were observed, and the concentrations of DDT metabolites (DDD and p,p’-DDE) increased over time. The carp organ with the highest concentrations of DDTs (DDT, DDD and DDE) was the gill. The largest mass distribution of DDTs was also in gill, followed by muscle and gastrointestinal tract. Maximum levels of DDTs in whole carp and carp muscle were 161 and 87 ng/g, respectively; therefore, the levels of DDTs observed in carp in this study were insufficient to constitute a health concern if present in fish for human consumption. Significant changes were observed in some biomarkers, including superoxide dismutase, catalase, glutathione-S-transferase, glutathione, and carboxylesterase, in T. tubifex and carp tissues during DDT exposure. Tissue-specific accumulation of DDTs in carp can be a key indicator of exposure to environmentally relevant concentrations.Shanshan DiRuiquan LiuZhongnan TianCheng ChengLi ChenWenjun ZhangZhiqiang ZhouJinling DiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shanshan Di Ruiquan Liu Zhongnan Tian Cheng Cheng Li Chen Wenjun Zhang Zhiqiang Zhou Jinling Diao Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web
description	Abstract Microcosms containing DDT spiked-sediment, Tubifex tubifex and carp (Cyprinus carpio) were constructed to simulate a freshwater system. The accumulation, elimination and toxic effects of DDT (p,p’-DDT, o,p’-DDT), and its metabolites DDD (p,p’-DDD, o,p’-DDD) and DDE (p,p’-DDE, o,p’-DDE) were studied in T. tubifex and carp. Tissue/organ distributions of DDTs were also investigated in carp. The bioaccumulation and elimination of DDT differed in T. tubifex, carp and its tissues/organs. Unimodal or bimodal distributions were observed, and the concentrations of DDT metabolites (DDD and p,p’-DDE) increased over time. The carp organ with the highest concentrations of DDTs (DDT, DDD and DDE) was the gill. The largest mass distribution of DDTs was also in gill, followed by muscle and gastrointestinal tract. Maximum levels of DDTs in whole carp and carp muscle were 161 and 87 ng/g, respectively; therefore, the levels of DDTs observed in carp in this study were insufficient to constitute a health concern if present in fish for human consumption. Significant changes were observed in some biomarkers, including superoxide dismutase, catalase, glutathione-S-transferase, glutathione, and carboxylesterase, in T. tubifex and carp tissues during DDT exposure. Tissue-specific accumulation of DDTs in carp can be a key indicator of exposure to environmentally relevant concentrations.
format	article
author	Shanshan Di Ruiquan Liu Zhongnan Tian Cheng Cheng Li Chen Wenjun Zhang Zhiqiang Zhou Jinling Diao
author_facet	Shanshan Di Ruiquan Liu Zhongnan Tian Cheng Cheng Li Chen Wenjun Zhang Zhiqiang Zhou Jinling Diao
author_sort	Shanshan Di
title	Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web
title_short	Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web
title_full	Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web
title_fullStr	Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web
title_full_unstemmed	Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web
title_sort	assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (ddts) in carp through aquatic food web
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6ed26a645e664ee5aa8a1044a7daf5a6
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Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web

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