Stem cell technology for bone regeneration: current status and potential applications

Greg Asatrian,1 Dalton Pham,1,2 Winters R Hardy,3 Aaron W James,1–3 Bruno Peault3,4 1Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, 2Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 3UCLA/Orthopaedic Hospital D...

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Autores principales:	Asatrian G, Pham D, Hardy WR, James AW, Peault B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/6ed37717291840299d499cbe8987a61e
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spelling	oai:doaj.org-article:6ed37717291840299d499cbe8987a61e2021-12-02T02:56:55ZStem cell technology for bone regeneration: current status and potential applications1178-6957https://doaj.org/article/6ed37717291840299d499cbe8987a61e2015-02-01T00:00:00Zhttp://www.dovepress.com/stem-cell-technology-for-bone-regeneration-current-status-and-potentia-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957 Greg Asatrian,1 Dalton Pham,1,2 Winters R Hardy,3 Aaron W James,1–3 Bruno Peault3,4 1Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, 2Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 3UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, CA, USA; 4Medical Research Council Centre for Regenerative Medicine, Edinburgh, Scotland, UK Abstract: Continued improvements in the understanding and application of mesenchymal stem cells (MSC) have revolutionized tissue engineering. This is particularly true within the field of skeletal regenerative medicine. However, much remains unknown regarding the native origins of MSC, the relative advantages of different MSC populations for bone regeneration, and even the biologic safety of such unpurified, grossly characterized cells. This review will first summarize the initial discovery of MSC, as well as the current and future applications of MSC in bone tissue engineering. Next, the relative advantages and disadvantages of MSC isolated from distinct tissue origins are debated, including the MSC from adipose, bone marrow, and dental pulp, among others. The perivascular origin of MSC is next discussed. Finally, we briefly comment on pluripotent stem cell populations and their possible application in bone tissue engineering. While continually expanding, the field of MSC-based bone tissue engineering and regeneration shows potential to become a clinical reality in the not-so-distant future.Keywords: mesenchymal stem cell, pericyte, bone tissue engineering, MSC, ASC, DMSCAsatrian GPham DHardy WRJames AWPeault BDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss default, Pp 39-48 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Asatrian G Pham D Hardy WR James AW Peault B Stem cell technology for bone regeneration: current status and potential applications
description	Greg Asatrian,1 Dalton Pham,1,2 Winters R Hardy,3 Aaron W James,1–3 Bruno Peault3,4 1Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, 2Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 3UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, Los Angeles, CA, USA; 4Medical Research Council Centre for Regenerative Medicine, Edinburgh, Scotland, UK Abstract: Continued improvements in the understanding and application of mesenchymal stem cells (MSC) have revolutionized tissue engineering. This is particularly true within the field of skeletal regenerative medicine. However, much remains unknown regarding the native origins of MSC, the relative advantages of different MSC populations for bone regeneration, and even the biologic safety of such unpurified, grossly characterized cells. This review will first summarize the initial discovery of MSC, as well as the current and future applications of MSC in bone tissue engineering. Next, the relative advantages and disadvantages of MSC isolated from distinct tissue origins are debated, including the MSC from adipose, bone marrow, and dental pulp, among others. The perivascular origin of MSC is next discussed. Finally, we briefly comment on pluripotent stem cell populations and their possible application in bone tissue engineering. While continually expanding, the field of MSC-based bone tissue engineering and regeneration shows potential to become a clinical reality in the not-so-distant future.Keywords: mesenchymal stem cell, pericyte, bone tissue engineering, MSC, ASC, DMSC
format	article
author	Asatrian G Pham D Hardy WR James AW Peault B
author_facet	Asatrian G Pham D Hardy WR James AW Peault B
author_sort	Asatrian G
title	Stem cell technology for bone regeneration: current status and potential applications
title_short	Stem cell technology for bone regeneration: current status and potential applications
title_full	Stem cell technology for bone regeneration: current status and potential applications
title_fullStr	Stem cell technology for bone regeneration: current status and potential applications
title_full_unstemmed	Stem cell technology for bone regeneration: current status and potential applications
title_sort	stem cell technology for bone regeneration: current status and potential applications
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/6ed37717291840299d499cbe8987a61e
work_keys_str_mv	AT asatriang stemcelltechnologyforboneregenerationcurrentstatusandpotentialapplications AT phamd stemcelltechnologyforboneregenerationcurrentstatusandpotentialapplications AT hardywr stemcelltechnologyforboneregenerationcurrentstatusandpotentialapplications AT jamesaw stemcelltechnologyforboneregenerationcurrentstatusandpotentialapplications AT peaultb stemcelltechnologyforboneregenerationcurrentstatusandpotentialapplications
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Stem cell technology for bone regeneration: current status and potential applications

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