Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.

Liposomes act as efficient drug carriers. Recently, epirubicin (EPI) formulation was developed using a novel EDTA ion gradient method for drug encapsulation. This formulation displayed very good stability and drug retention in vitro in a two-year long-term stability experiment. The cryo-TEM images s...

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Autores principales:	Jerzy Gubernator, Dominik Lipka, Mariola Korycińska, Katarzyna Kempińska, Magdalena Milczarek, Joanna Wietrzyk, Rafał Hrynyk, Sabine Barnert, Regine Süss, Arkadiusz Kozubek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6ed88cd774154c58842be34e310f3b09
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spelling	oai:doaj.org-article:6ed88cd774154c58842be34e310f3b092021-11-18T08:28:32ZEfficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.1932-620310.1371/journal.pone.0091487https://doaj.org/article/6ed88cd774154c58842be34e310f3b092014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24621591/?tool=EBIhttps://doaj.org/toc/1932-6203Liposomes act as efficient drug carriers. Recently, epirubicin (EPI) formulation was developed using a novel EDTA ion gradient method for drug encapsulation. This formulation displayed very good stability and drug retention in vitro in a two-year long-term stability experiment. The cryo-TEM images show drug precipitate structures different than ones formed with ammonium sulfate method, which is usually used to encapsulate anthracyclines. Its pharmacokinetic properties and its efficacy in the human breast MDA-MB-231 cancer xenograft model were also determined. The liposomal EPI formulation is eliminated slowly with an AUC of 7.6487, while the free drug has an AUC of only 0.0097. The formulation also had a much higher overall antitumor efficacy than the free drug.Jerzy GubernatorDominik LipkaMariola KorycińskaKatarzyna KempińskaMagdalena MilczarekJoanna WietrzykRafał HrynykSabine BarnertRegine SüssArkadiusz KozubekPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e91487 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jerzy Gubernator Dominik Lipka Mariola Korycińska Katarzyna Kempińska Magdalena Milczarek Joanna Wietrzyk Rafał Hrynyk Sabine Barnert Regine Süss Arkadiusz Kozubek Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
description	Liposomes act as efficient drug carriers. Recently, epirubicin (EPI) formulation was developed using a novel EDTA ion gradient method for drug encapsulation. This formulation displayed very good stability and drug retention in vitro in a two-year long-term stability experiment. The cryo-TEM images show drug precipitate structures different than ones formed with ammonium sulfate method, which is usually used to encapsulate anthracyclines. Its pharmacokinetic properties and its efficacy in the human breast MDA-MB-231 cancer xenograft model were also determined. The liposomal EPI formulation is eliminated slowly with an AUC of 7.6487, while the free drug has an AUC of only 0.0097. The formulation also had a much higher overall antitumor efficacy than the free drug.
format	article
author	Jerzy Gubernator Dominik Lipka Mariola Korycińska Katarzyna Kempińska Magdalena Milczarek Joanna Wietrzyk Rafał Hrynyk Sabine Barnert Regine Süss Arkadiusz Kozubek
author_facet	Jerzy Gubernator Dominik Lipka Mariola Korycińska Katarzyna Kempińska Magdalena Milczarek Joanna Wietrzyk Rafał Hrynyk Sabine Barnert Regine Süss Arkadiusz Kozubek
author_sort	Jerzy Gubernator
title	Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_short	Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_full	Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_fullStr	Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_full_unstemmed	Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.
title_sort	efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the edta ion gradient method.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/6ed88cd774154c58842be34e310f3b09
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Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.

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