A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity

Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for ada...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lei Yuan, Gary C. Chan, David Beeler, Lauren Janes, Katherine C. Spokes, Harita Dharaneeswaran, Anahita Mojiri, William J. Adams, Tracey Sciuto, Guillermo Garcia-Cardeña, Grietje Molema, Peter M. Kang, Nadia Jahroudi, Philip A. Marsden, Ann Dvorak, Erzsébet Ravasz Regan, William C. Aird
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6ed9333a2a8b469cb9f3182d7d55819d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6ed9333a2a8b469cb9f3182d7d55819d
record_format	dspace
spelling	oai:doaj.org-article:6ed9333a2a8b469cb9f3182d7d55819d2021-12-02T16:49:59ZA role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity10.1038/ncomms101602041-1723https://doaj.org/article/6ed9333a2a8b469cb9f3182d7d55819d2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10160https://doaj.org/toc/2041-1723Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for adaptive homeostasis.Lei YuanGary C. ChanDavid BeelerLauren JanesKatherine C. SpokesHarita DharaneeswaranAnahita MojiriWilliam J. AdamsTracey SciutoGuillermo Garcia-CardeñaGrietje MolemaPeter M. KangNadia JahroudiPhilip A. MarsdenAnn DvorakErzsébet Ravasz ReganWilliam C. AirdNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Yuan Gary C. Chan David Beeler Lauren Janes Katherine C. Spokes Harita Dharaneeswaran Anahita Mojiri William J. Adams Tracey Sciuto Guillermo Garcia-Cardeña Grietje Molema Peter M. Kang Nadia Jahroudi Philip A. Marsden Ann Dvorak Erzsébet Ravasz Regan William C. Aird A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
description	Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand factor, suggesting bet hedging as a strategy for adaptive homeostasis.
format	article
author	Lei Yuan Gary C. Chan David Beeler Lauren Janes Katherine C. Spokes Harita Dharaneeswaran Anahita Mojiri William J. Adams Tracey Sciuto Guillermo Garcia-Cardeña Grietje Molema Peter M. Kang Nadia Jahroudi Philip A. Marsden Ann Dvorak Erzsébet Ravasz Regan William C. Aird
author_facet	Lei Yuan Gary C. Chan David Beeler Lauren Janes Katherine C. Spokes Harita Dharaneeswaran Anahita Mojiri William J. Adams Tracey Sciuto Guillermo Garcia-Cardeña Grietje Molema Peter M. Kang Nadia Jahroudi Philip A. Marsden Ann Dvorak Erzsébet Ravasz Regan William C. Aird
author_sort	Lei Yuan
title	A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
title_short	A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
title_full	A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
title_fullStr	A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
title_full_unstemmed	A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
title_sort	role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6ed9333a2a8b469cb9f3182d7d55819d
work_keys_str_mv	AT leiyuan aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT garycchan aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT davidbeeler aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT laurenjanes aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT katherinecspokes aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT haritadharaneeswaran aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT anahitamojiri aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT williamjadams aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT traceysciuto aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT guillermogarciacardena aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT grietjemolema aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT petermkang aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT nadiajahroudi aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT philipamarsden aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT anndvorak aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT erzsebetravaszregan aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT williamcaird aroleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT leiyuan roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT garycchan roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT davidbeeler roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT laurenjanes roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT katherinecspokes roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT haritadharaneeswaran roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT anahitamojiri roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT williamjadams roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT traceysciuto roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT guillermogarciacardena roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT grietjemolema roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT petermkang roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT nadiajahroudi roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT philipamarsden roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT anndvorak roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT erzsebetravaszregan roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity AT williamcaird roleofstochasticphenotypeswitchingingeneratingmosaicendothelialcellheterogeneity
_version_	1718383163323973632

A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity

Ejemplares similares