Prostaglandins in biofluids in pregnancy and labour: A systematic review.

Prostaglandins are thought to be important mediators in the initiation of human labour, however the evidence supporting this is not entirely clear. Determining how, and which, prostaglandins change during pregnancy and labour may provide insight into mechanisms governing labour initiation and the po...

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Autores principales:	Eilidh M Wood, Kylie K Hornaday, Donna M Slater
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6eda034730d041a2b6a37c219894c4a1
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spelling	oai:doaj.org-article:6eda034730d041a2b6a37c219894c4a12021-12-02T20:12:46ZProstaglandins in biofluids in pregnancy and labour: A systematic review.1932-620310.1371/journal.pone.0260115https://doaj.org/article/6eda034730d041a2b6a37c219894c4a12021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260115https://doaj.org/toc/1932-6203Prostaglandins are thought to be important mediators in the initiation of human labour, however the evidence supporting this is not entirely clear. Determining how, and which, prostaglandins change during pregnancy and labour may provide insight into mechanisms governing labour initiation and the potential to predict timing of labour onset. The current study systematically searched the existing scientific literature to determine how biofluid levels of prostaglandins change throughout pregnancy before and during labour, and whether prostaglandins and/or their metabolites may be useful for prediction of labour. The databases EMBASE and MEDLINE were searched for English-language articles on prostaglandins measured in plasma, serum, amniotic fluid, or urine during pregnancy and/or spontaneous labour. Studies were assessed for quality and risk of bias and a qualitative summary of included studies was generated. Our review identified 83 studies published between 1968-2021 that met the inclusion criteria. As measured in amniotic fluid, levels of PGE2, along with PGF2α and its metabolite 13,14-dihydro-15-keto-PGF2α were reported higher in labour compared to non-labour. In blood, only 13,14-dihydro-15-keto-PGF2α was reported higher in labour. Additionally, PGF2α, PGF1α, and PGE2 were reported to increase in amniotic fluid as pregnancy progressed, though this pattern was not consistent in plasma. Overall, the evidence supporting changes in prostaglandin levels in these biofluids remains unclear. An important limitation is the lack of data on the complexity of the prostaglandin pathway outside of the PGE and PGF families. Future studies using new methodologies capable of co-assessing multiple prostaglandins and metabolites, in large, well-defined populations, will help provide more insight as to the identification of exactly which prostaglandins and/or metabolites consistently change with labour. Revisiting and revising our understanding of the prostaglandins may provide better targets for clinical monitoring of pregnancies. This study was supported by the Canadian Institutes of Health Research.Eilidh M WoodKylie K HornadayDonna M SlaterPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260115 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eilidh M Wood Kylie K Hornaday Donna M Slater Prostaglandins in biofluids in pregnancy and labour: A systematic review.
description	Prostaglandins are thought to be important mediators in the initiation of human labour, however the evidence supporting this is not entirely clear. Determining how, and which, prostaglandins change during pregnancy and labour may provide insight into mechanisms governing labour initiation and the potential to predict timing of labour onset. The current study systematically searched the existing scientific literature to determine how biofluid levels of prostaglandins change throughout pregnancy before and during labour, and whether prostaglandins and/or their metabolites may be useful for prediction of labour. The databases EMBASE and MEDLINE were searched for English-language articles on prostaglandins measured in plasma, serum, amniotic fluid, or urine during pregnancy and/or spontaneous labour. Studies were assessed for quality and risk of bias and a qualitative summary of included studies was generated. Our review identified 83 studies published between 1968-2021 that met the inclusion criteria. As measured in amniotic fluid, levels of PGE2, along with PGF2α and its metabolite 13,14-dihydro-15-keto-PGF2α were reported higher in labour compared to non-labour. In blood, only 13,14-dihydro-15-keto-PGF2α was reported higher in labour. Additionally, PGF2α, PGF1α, and PGE2 were reported to increase in amniotic fluid as pregnancy progressed, though this pattern was not consistent in plasma. Overall, the evidence supporting changes in prostaglandin levels in these biofluids remains unclear. An important limitation is the lack of data on the complexity of the prostaglandin pathway outside of the PGE and PGF families. Future studies using new methodologies capable of co-assessing multiple prostaglandins and metabolites, in large, well-defined populations, will help provide more insight as to the identification of exactly which prostaglandins and/or metabolites consistently change with labour. Revisiting and revising our understanding of the prostaglandins may provide better targets for clinical monitoring of pregnancies. This study was supported by the Canadian Institutes of Health Research.
format	article
author	Eilidh M Wood Kylie K Hornaday Donna M Slater
author_facet	Eilidh M Wood Kylie K Hornaday Donna M Slater
author_sort	Eilidh M Wood
title	Prostaglandins in biofluids in pregnancy and labour: A systematic review.
title_short	Prostaglandins in biofluids in pregnancy and labour: A systematic review.
title_full	Prostaglandins in biofluids in pregnancy and labour: A systematic review.
title_fullStr	Prostaglandins in biofluids in pregnancy and labour: A systematic review.
title_full_unstemmed	Prostaglandins in biofluids in pregnancy and labour: A systematic review.
title_sort	prostaglandins in biofluids in pregnancy and labour: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6eda034730d041a2b6a37c219894c4a1
work_keys_str_mv	AT eilidhmwood prostaglandinsinbiofluidsinpregnancyandlabourasystematicreview AT kyliekhornaday prostaglandinsinbiofluidsinpregnancyandlabourasystematicreview AT donnamslater prostaglandinsinbiofluidsinpregnancyandlabourasystematicreview
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Prostaglandins in biofluids in pregnancy and labour: A systematic review.

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