The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.

The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement.

Nef is a multifunctional HIV-1 protein that accelerates progression to AIDS, and enhances the infectivity of progeny viruses through a mechanism that is not yet understood. Here, we show that the small molecule compound 2c reduces Nef-mediated viral infectivity enhancement. When added to viral produ...

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Autores principales: Nopporn Chutiwitoonchai, Masateru Hiyoshi, Philip Mwimanzi, Takamasa Ueno, Akio Adachi, Hirotaka Ode, Hironori Sato, Oliver T Fackler, Seiji Okada, Shinya Suzu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6edaba99480b4faaa96bd8138c571c9b
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