Hormones in experimental autoimmune encephalomyelitis (EAE) animal models

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination. While the etiology of MS is still largely unknown, the interaction between hormones and the immune system play...

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Autores principales:	Ghareghani Majid, Ghanbari Amir, Eid Ali, Shaito Abdullah, Mohamed Wael, Mondello Stefania, Zibara Kazem
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	multiple sclerosis experimental autoimmune encephalomyelitis eae endocrine system hormone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/6ee955e123ca4d9d8e2e274c46e4fd16
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spelling	oai:doaj.org-article:6ee955e123ca4d9d8e2e274c46e4fd162021-12-05T14:11:05ZHormones in experimental autoimmune encephalomyelitis (EAE) animal models2081-693610.1515/tnsci-2020-0169https://doaj.org/article/6ee955e123ca4d9d8e2e274c46e4fd162021-05-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0169https://doaj.org/toc/2081-6936Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination. While the etiology of MS is still largely unknown, the interaction between hormones and the immune system plays a role in disease progression, but the mechanisms by which this occurs are incompletely understood. Several in vitro and in vivo experimental, but also clinical studies, have addressed the possible role of the endocrine system in susceptibility and severity of autoimmune diseases. Although there are several demyelinating models, experimental autoimmune encephalomyelitis (EAE) is the oldest and most commonly used model for MS in laboratory animals which enables researchers to translate their findings from EAE into human. Evidences imply that there is great heterogeneity in the susceptibility to the induction, the method of induction, and the response to various immunological or pharmacological interventions, which led to conflicting results on the role of specific hormones in the EAE model. In this review, we address the role of endocrine system in EAE model to provide a comprehensive view and a better understanding of the interactions between the endocrine and the immune systems in various models of EAE, to open up a ground for further detailed studies in this field by considering and comparing the results and models used in previous studies.Ghareghani MajidGhanbari AmirEid AliShaito AbdullahMohamed WaelMondello StefaniaZibara KazemDe Gruyterarticlemultiple sclerosisexperimental autoimmune encephalomyelitiseaeendocrine systemhormoneNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 164-189 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis experimental autoimmune encephalomyelitis eae endocrine system hormone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	multiple sclerosis experimental autoimmune encephalomyelitis eae endocrine system hormone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ghareghani Majid Ghanbari Amir Eid Ali Shaito Abdullah Mohamed Wael Mondello Stefania Zibara Kazem Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
description	Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) in which activated immune cells attack the CNS and cause inflammation and demyelination. While the etiology of MS is still largely unknown, the interaction between hormones and the immune system plays a role in disease progression, but the mechanisms by which this occurs are incompletely understood. Several in vitro and in vivo experimental, but also clinical studies, have addressed the possible role of the endocrine system in susceptibility and severity of autoimmune diseases. Although there are several demyelinating models, experimental autoimmune encephalomyelitis (EAE) is the oldest and most commonly used model for MS in laboratory animals which enables researchers to translate their findings from EAE into human. Evidences imply that there is great heterogeneity in the susceptibility to the induction, the method of induction, and the response to various immunological or pharmacological interventions, which led to conflicting results on the role of specific hormones in the EAE model. In this review, we address the role of endocrine system in EAE model to provide a comprehensive view and a better understanding of the interactions between the endocrine and the immune systems in various models of EAE, to open up a ground for further detailed studies in this field by considering and comparing the results and models used in previous studies.
format	article
author	Ghareghani Majid Ghanbari Amir Eid Ali Shaito Abdullah Mohamed Wael Mondello Stefania Zibara Kazem
author_facet	Ghareghani Majid Ghanbari Amir Eid Ali Shaito Abdullah Mohamed Wael Mondello Stefania Zibara Kazem
author_sort	Ghareghani Majid
title	Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
title_short	Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
title_full	Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
title_fullStr	Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
title_full_unstemmed	Hormones in experimental autoimmune encephalomyelitis (EAE) animal models
title_sort	hormones in experimental autoimmune encephalomyelitis (eae) animal models
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/6ee955e123ca4d9d8e2e274c46e4fd16
work_keys_str_mv	AT ghareghanimajid hormonesinexperimentalautoimmuneencephalomyelitiseaeanimalmodels AT ghanbariamir hormonesinexperimentalautoimmuneencephalomyelitiseaeanimalmodels AT eidali hormonesinexperimentalautoimmuneencephalomyelitiseaeanimalmodels AT shaitoabdullah hormonesinexperimentalautoimmuneencephalomyelitiseaeanimalmodels AT mohamedwael hormonesinexperimentalautoimmuneencephalomyelitiseaeanimalmodels AT mondellostefania hormonesinexperimentalautoimmuneencephalomyelitiseaeanimalmodels AT zibarakazem hormonesinexperimentalautoimmuneencephalomyelitiseaeanimalmodels
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Hormones in experimental autoimmune encephalomyelitis (EAE) animal models

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