The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection

Abstract The concern of today's communities is to find a way to prevent or treat COVID-19 and reduce its symptoms in the patients. However, the genetic mutations and more resistant strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge; the designed vaccines and adjuvant...

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Autores principales:	Mohsen Nabi-Afjadi, Hadis Karami, Kaveh Goudarzi, Iraj Alipourfard, Elham Bahreini
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 Interferon Vitamin D Magnesium Zinc Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6ee99cf356c448dda13659bd4c74589e
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spelling	oai:doaj.org-article:6ee99cf356c448dda13659bd4c74589e2021-11-14T12:24:54ZThe effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection10.1186/s12948-021-00161-w1476-7961https://doaj.org/article/6ee99cf356c448dda13659bd4c74589e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12948-021-00161-whttps://doaj.org/toc/1476-7961Abstract The concern of today's communities is to find a way to prevent or treat COVID-19 and reduce its symptoms in the patients. However, the genetic mutations and more resistant strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge; the designed vaccines and adjuvant therapies would potentially control the symptoms and severity of COVID-19. The most important complication of this viral infection is acute respiratory distress syndrome, which occurs due to the infiltration of leukocytes into the alveoli and the raised cytokine storm. Interferons, as a cytokine family in the host, play an important role in the immune-related antiviral defense and have been considered in the treatment protocols of COVID-19. In addition, it has been indicated that some nutrients, including vitamin D, magnesium and zinc are essential in the modulation of the immune system and interferon (IFN) signaling pathway. Several recent studies have investigated the treatment effect of vitamin D on COVID-19 and reported the association between optimal levels of this vitamin and reduced disease risk. In the present study, the synergistic action of vitamin D, magnesium and zinc in IFN signaling is discussed as a treatment option for COVID-19 involvement.Mohsen Nabi-AfjadiHadis KaramiKaveh GoudarziIraj AlipourfardElham BahreiniBMCarticleCOVID-19InterferonVitamin DMagnesiumZincImmunologic diseases. AllergyRC581-607ENClinical and Molecular Allergy, Vol 19, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Interferon Vitamin D Magnesium Zinc Immunologic diseases. Allergy RC581-607
spellingShingle	COVID-19 Interferon Vitamin D Magnesium Zinc Immunologic diseases. Allergy RC581-607 Mohsen Nabi-Afjadi Hadis Karami Kaveh Goudarzi Iraj Alipourfard Elham Bahreini The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
description	Abstract The concern of today's communities is to find a way to prevent or treat COVID-19 and reduce its symptoms in the patients. However, the genetic mutations and more resistant strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge; the designed vaccines and adjuvant therapies would potentially control the symptoms and severity of COVID-19. The most important complication of this viral infection is acute respiratory distress syndrome, which occurs due to the infiltration of leukocytes into the alveoli and the raised cytokine storm. Interferons, as a cytokine family in the host, play an important role in the immune-related antiviral defense and have been considered in the treatment protocols of COVID-19. In addition, it has been indicated that some nutrients, including vitamin D, magnesium and zinc are essential in the modulation of the immune system and interferon (IFN) signaling pathway. Several recent studies have investigated the treatment effect of vitamin D on COVID-19 and reported the association between optimal levels of this vitamin and reduced disease risk. In the present study, the synergistic action of vitamin D, magnesium and zinc in IFN signaling is discussed as a treatment option for COVID-19 involvement.
format	article
author	Mohsen Nabi-Afjadi Hadis Karami Kaveh Goudarzi Iraj Alipourfard Elham Bahreini
author_facet	Mohsen Nabi-Afjadi Hadis Karami Kaveh Goudarzi Iraj Alipourfard Elham Bahreini
author_sort	Mohsen Nabi-Afjadi
title	The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
title_short	The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
title_full	The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
title_fullStr	The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
title_full_unstemmed	The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
title_sort	effect of vitamin d, magnesium and zinc supplements on interferon signaling pathways and their relationship to control sars-cov-2 infection
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6ee99cf356c448dda13659bd4c74589e
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The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection

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